Cytokine and chemokine profiles during early induction
| Assays . | C1D1 median, pg/mL . | C2D1 median, pg/mL . | C4D1 median, pg/mL . | P (C1 vs C2) . | P (C1 vs C2)* . | P (C1 vs C4) . | P (C1 vs C4)* . |
|---|---|---|---|---|---|---|---|
| Cytokines | |||||||
| IFN-γ | 6.185 | 6.398 | 8.253 | .004 | .036 | .007 | .063 |
| TNF-α | 21.500 | 5.840 | 4.433 | <.0001 | .001 | <.0001 | .001 |
| IL-2 | 0.275 | 0.117 | 0.139 | .046 | .414 | .032 | .288 |
| IL-4 | 0.000 | 0.008 | 0.001 | .004 | .036 | .017 | .153 |
| IL-6 | 0.974 | 0.815 | 0.768 | .065 | .585 | .122 | 1.000 |
| IL-8 | 4.955 | 4.718 | 5.615 | .864 | 1.000 | .210 | 1.000 |
| IL-10 | 1.575 | 0.936 | 0.780 | .004 | .036 | .007 | .063 |
| IL-12p70 | 0.041 | 0.058 | 0.047 | .202 | 1.000 | .982 | 1.000 |
| IL-13 | .471 | 0.396 | 0.347 | .869 | 1.000 | .841 | 1.000 |
| Chemokines | |||||||
| MCP1 | 34.850 | 22.725 | 22.575 | <.0001 | .001 | .001 | .009 |
| MCP4 | 19.700 | 25.050 | 20.025 | .032 | .288 | .255 | 1.000 |
| Eotaxin | 72.550 | 67.850 | 63.125 | .053 | .477 | .034 | .306 |
| Eotaxin3 | 21.800 | 20.050 | 16.013 | .452 | 1.000 | .007 | .063 |
| IP-10 | 193.500 | 179.000 | 185.500 | .032 | .288 | .624 | 1.000 |
| MDC | 686.500 | 325.000 | 291.500 | <.0001 | .001 | <.0001 | .001 |
| TARC | 30.400 | 31.725 | 19.925 | .339 | 1.000 | .265 | 1.000 |
| MIP1α | 20.300 | 13.600 | 9.828 | .007 | .063 | .001 | .009 |
| MIP1β | 75.750 | 35.175 | 34.525 | <.0001 | .001 | <.0001 | .001 |
| Assays . | C1D1 median, pg/mL . | C2D1 median, pg/mL . | C4D1 median, pg/mL . | P (C1 vs C2) . | P (C1 vs C2)* . | P (C1 vs C4) . | P (C1 vs C4)* . |
|---|---|---|---|---|---|---|---|
| Cytokines | |||||||
| IFN-γ | 6.185 | 6.398 | 8.253 | .004 | .036 | .007 | .063 |
| TNF-α | 21.500 | 5.840 | 4.433 | <.0001 | .001 | <.0001 | .001 |
| IL-2 | 0.275 | 0.117 | 0.139 | .046 | .414 | .032 | .288 |
| IL-4 | 0.000 | 0.008 | 0.001 | .004 | .036 | .017 | .153 |
| IL-6 | 0.974 | 0.815 | 0.768 | .065 | .585 | .122 | 1.000 |
| IL-8 | 4.955 | 4.718 | 5.615 | .864 | 1.000 | .210 | 1.000 |
| IL-10 | 1.575 | 0.936 | 0.780 | .004 | .036 | .007 | .063 |
| IL-12p70 | 0.041 | 0.058 | 0.047 | .202 | 1.000 | .982 | 1.000 |
| IL-13 | .471 | 0.396 | 0.347 | .869 | 1.000 | .841 | 1.000 |
| Chemokines | |||||||
| MCP1 | 34.850 | 22.725 | 22.575 | <.0001 | .001 | .001 | .009 |
| MCP4 | 19.700 | 25.050 | 20.025 | .032 | .288 | .255 | 1.000 |
| Eotaxin | 72.550 | 67.850 | 63.125 | .053 | .477 | .034 | .306 |
| Eotaxin3 | 21.800 | 20.050 | 16.013 | .452 | 1.000 | .007 | .063 |
| IP-10 | 193.500 | 179.000 | 185.500 | .032 | .288 | .624 | 1.000 |
| MDC | 686.500 | 325.000 | 291.500 | <.0001 | .001 | <.0001 | .001 |
| TARC | 30.400 | 31.725 | 19.925 | .339 | 1.000 | .265 | 1.000 |
| MIP1α | 20.300 | 13.600 | 9.828 | .007 | .063 | .001 | .009 |
| MIP1β | 75.750 | 35.175 | 34.525 | <.0001 | .001 | <.0001 | .001 |
P values were derived from the Wilcoxon signed-rank test that compares medians.
C1, cycle 1; C1D1, cycle 1 day 1; C2, cycle 2; C4, cycle 4.
P values were derived from Bonferroni-corrected Wilcoxon signed-rank tests that compare medians.