Table 1.

Human Fc receptors

Classical FcγRNonclassical FcR
FcγRIFcγRIIaFcγRIIbFcγRIIcFcγRIIIaFcγRIIIbFcRnDC-SIGNCD22CD23TRIM21FCRL1-6FCRLAFCRLB
Other name CD64 CD32A CD32B CD32C CD16A CD16B Brambell receptor CD209; CLEC4L SIGLEC2 FcεRII Ro52 CD307a-f   
Cellular distribution Surface plasma membrane Surface and endosomes Surface plasma membrane Surface Cytoplasmic Surface Intracellular compartments 
Functional outcome Activation Inhibition Activation IgG recycling; circulating immune complex responses Ag presentation Inhibition Activation Activation; viral degradation Inhibition/ activation? IgG retention during affinity maturation? 
Cellular expression Hematopoietic Most nucleated cells Myeloid B cells Hematopoietic; epithelia Most nucleated cells Lymphocytes; mainly B cells Germinal center B cells 
Ig-binding affinity IgG, high IgG, low/medium IgG, high; pH dependent Sialylated IgG, medium Sialylated glycans, surface IgM, CD45 IgE, low IgG, IgM, and IgA, medium IgG aggregates, low/medium IgG, low 
Classical FcγRNonclassical FcR
FcγRIFcγRIIaFcγRIIbFcγRIIcFcγRIIIaFcγRIIIbFcRnDC-SIGNCD22CD23TRIM21FCRL1-6FCRLAFCRLB
Other name CD64 CD32A CD32B CD32C CD16A CD16B Brambell receptor CD209; CLEC4L SIGLEC2 FcεRII Ro52 CD307a-f   
Cellular distribution Surface plasma membrane Surface and endosomes Surface plasma membrane Surface Cytoplasmic Surface Intracellular compartments 
Functional outcome Activation Inhibition Activation IgG recycling; circulating immune complex responses Ag presentation Inhibition Activation Activation; viral degradation Inhibition/ activation? IgG retention during affinity maturation? 
Cellular expression Hematopoietic Most nucleated cells Myeloid B cells Hematopoietic; epithelia Most nucleated cells Lymphocytes; mainly B cells Germinal center B cells 
Ig-binding affinity IgG, high IgG, low/medium IgG, high; pH dependent Sialylated IgG, medium Sialylated glycans, surface IgM, CD45 IgE, low IgG, IgM, and IgA, medium IgG aggregates, low/medium IgG, low 
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