Genes with isoforms that significantly predicted survival in MDS in multivariate models
| Gene . | Associated splice factor mutation or mutations . | Function/pathway . | P (multivariate survival) . |
|---|---|---|---|
| CAP1 | SRSF2 | Focal adhesion & extracellular exosomes | .0044 |
| PTPRC | U2AF1 (S34) | Focal adhesion & extracellular exosomes | .0093 |
| IFI44 | SRSF2, U2AF1 (S34) | Interferon, extracellular exosomes | .012 |
| IFI44L | U2AF1 (S34) | Interferon, extracellular exosomes | .0086 |
| CD46 | U2AF1 (S34) | Focal adhesion & extracellular exosomes | .039 |
| CRTC2 | SF3B1 | Extracellular exosomes | .035 |
| FCGR2A | U2AF1 (S34) | Extracellular exosomes | .016 |
| PPOX | SF3B1, U2AF1 (R156/Q157) | Heme biosynthesis | .031 |
| AHSA2 | SF3B1 | HSP90 ATPase | .029 |
| DHP5 | SF3B1 | Translation elongation factor 2 modification | .026 |
| MECR | U2AF1 (S34 & R156/Q157) | Mitochondrial reductase | .022 |
| NASP | U2AF1 (S34) | HSP90 binding | .014 |
| PFDN5 | U2AF1 (R156/Q157) | Prefoldin subunit | .042 |
| PABPC4 | U2AF1 (R156/Q157) | NMD mRNA decay | .036 |
| Gene . | Associated splice factor mutation or mutations . | Function/pathway . | P (multivariate survival) . |
|---|---|---|---|
| CAP1 | SRSF2 | Focal adhesion & extracellular exosomes | .0044 |
| PTPRC | U2AF1 (S34) | Focal adhesion & extracellular exosomes | .0093 |
| IFI44 | SRSF2, U2AF1 (S34) | Interferon, extracellular exosomes | .012 |
| IFI44L | U2AF1 (S34) | Interferon, extracellular exosomes | .0086 |
| CD46 | U2AF1 (S34) | Focal adhesion & extracellular exosomes | .039 |
| CRTC2 | SF3B1 | Extracellular exosomes | .035 |
| FCGR2A | U2AF1 (S34) | Extracellular exosomes | .016 |
| PPOX | SF3B1, U2AF1 (R156/Q157) | Heme biosynthesis | .031 |
| AHSA2 | SF3B1 | HSP90 ATPase | .029 |
| DHP5 | SF3B1 | Translation elongation factor 2 modification | .026 |
| MECR | U2AF1 (S34 & R156/Q157) | Mitochondrial reductase | .022 |
| NASP | U2AF1 (S34) | HSP90 binding | .014 |
| PFDN5 | U2AF1 (R156/Q157) | Prefoldin subunit | .042 |
| PABPC4 | U2AF1 (R156/Q157) | NMD mRNA decay | .036 |