List of aberrant splicing events, identified in SF3B1mut MDS, significantly correlated with a clinical variable
| Event ID . | Gene . | Event type . | Chr . | Strand . | Start position . | End position . | Spearman correlation variable . | cor_estimate . | P . | adj.P . |
|---|---|---|---|---|---|---|---|---|---|---|
| 6795 | PARVG | A3SS | 22 | + | 44582456 | 44583758 | BM blast % | 0.58 | 4.38E-07 | .003031 |
| 5420 | RPRD1A | RI | 18 | − | 33605560 | 33607038 | BM blast % | 0.58 | 6.21E-07 | .004292 |
| 3146 | DOM3Z | RI | 6 | − | 31938382 | 31938924 | ANC | −0.57 | 1.00E-06 | .006916 |
| 12280 | CXXC1 | SE | 18 | − | 47811694 | 47811721 | ANC | −0.56 | 1.28E-06 | .00888 |
| 3305 | AP1G2 | RI | 14 | − | 24031170 | 24031624 | ANC | −0.56 | 1.68E-06 | .011579 |
| 2362 | SNRPN | A3SS | 15 | + | 25219434 | 25219603 | ANC | −0.55 | 3.14E-06 | .021689 |
| 5460 | TCEA2 | A3SS | 20 | + | 62703210 | 62703294 | ANC | 0.54 | 3.24E-06 | .022393 |
| 6627 | NICN1 | A3SS | 3 | − | 49462381 | 49462579 | Plt | −0.54 | 3.80E-06 | .026281 |
| 6153 | ABCC5 | A3SS | 3 | − | 183703091 | 183703243 | ANC | −0.54 | 4.23E-06 | .029229 |
| 518 | ERCC3 | RI | 2 | − | 128046912 | 128047400 | ANC | −0.54 | 4.71E-06 | .032551 |
| 2359 | SNRPN | A3SS | 15 | + | 25219457 | 25219603 | ANC | −0.54 | 5.02E-06 | .03468 |
| 7563 | PPOX | A3SS | 1 | + | 161137128 | 161137276 | ANC | 0.53 | 5.99E-06 | .041411 |
| 4975 | GPR108 | A3SS | 19 | − | 6730997 | 6731122 | ANC | −0.53 | 6.43E-06 | .044443 |
| 5816 | PSTPIP1 | A3SS | 15 | + | 77328142 | 77328276 | ANC | −0.53 | 6.49E-06 | .044832 |
| 4728 | NICN1 | RI | 3 | − | 49462381 | 49462871 | Plt | −0.53 | 6.75E-06 | .046655 |
| Event ID . | Gene . | Event type . | Chr . | Strand . | Start position . | End position . | Spearman correlation variable . | cor_estimate . | P . | adj.P . |
|---|---|---|---|---|---|---|---|---|---|---|
| 6795 | PARVG | A3SS | 22 | + | 44582456 | 44583758 | BM blast % | 0.58 | 4.38E-07 | .003031 |
| 5420 | RPRD1A | RI | 18 | − | 33605560 | 33607038 | BM blast % | 0.58 | 6.21E-07 | .004292 |
| 3146 | DOM3Z | RI | 6 | − | 31938382 | 31938924 | ANC | −0.57 | 1.00E-06 | .006916 |
| 12280 | CXXC1 | SE | 18 | − | 47811694 | 47811721 | ANC | −0.56 | 1.28E-06 | .00888 |
| 3305 | AP1G2 | RI | 14 | − | 24031170 | 24031624 | ANC | −0.56 | 1.68E-06 | .011579 |
| 2362 | SNRPN | A3SS | 15 | + | 25219434 | 25219603 | ANC | −0.55 | 3.14E-06 | .021689 |
| 5460 | TCEA2 | A3SS | 20 | + | 62703210 | 62703294 | ANC | 0.54 | 3.24E-06 | .022393 |
| 6627 | NICN1 | A3SS | 3 | − | 49462381 | 49462579 | Plt | −0.54 | 3.80E-06 | .026281 |
| 6153 | ABCC5 | A3SS | 3 | − | 183703091 | 183703243 | ANC | −0.54 | 4.23E-06 | .029229 |
| 518 | ERCC3 | RI | 2 | − | 128046912 | 128047400 | ANC | −0.54 | 4.71E-06 | .032551 |
| 2359 | SNRPN | A3SS | 15 | + | 25219457 | 25219603 | ANC | −0.54 | 5.02E-06 | .03468 |
| 7563 | PPOX | A3SS | 1 | + | 161137128 | 161137276 | ANC | 0.53 | 5.99E-06 | .041411 |
| 4975 | GPR108 | A3SS | 19 | − | 6730997 | 6731122 | ANC | −0.53 | 6.43E-06 | .044443 |
| 5816 | PSTPIP1 | A3SS | 15 | + | 77328142 | 77328276 | ANC | −0.53 | 6.49E-06 | .044832 |
| 4728 | NICN1 | RI | 3 | − | 49462381 | 49462871 | Plt | −0.53 | 6.75E-06 | .046655 |
ANC, absolute neutrophil count; BM blast %, bone marrow blast percentage; Plt, platelet count.