Frequency of kinase alterations in SR ALL
| Subgroup . | NCI SR, n (%) (n = 1023) . |
|---|---|
| Ph-like ALL | 139 (13.6) |
| CRLF2-R | 41 (4) |
| IGH-CRLF2 | 5 (0.5) |
| P2RY8-CRLF2 | 36 (3.5) |
| CRLF2-R with JAK-STAT mutation | 14 (1.7) |
| CRLF2-R without JAK-STAT mutation | 27 (2.6) |
| Non-CRLF2 | 98 (9.6) |
| ABL1-class fusions | 2 (0.2) |
| JAK2-R | 2 (0.2) |
| EPOR-R | 0 |
| NTRK3-R | 1 (0.1) |
| Other JAK-STAT | 2 (0.2) |
| Ras | 6 (0.6) |
| No kinase identified | 56 (5.5) |
| Not tested | 29 (2.8) |
| Subgroup . | NCI SR, n (%) (n = 1023) . |
|---|---|
| Ph-like ALL | 139 (13.6) |
| CRLF2-R | 41 (4) |
| IGH-CRLF2 | 5 (0.5) |
| P2RY8-CRLF2 | 36 (3.5) |
| CRLF2-R with JAK-STAT mutation | 14 (1.7) |
| CRLF2-R without JAK-STAT mutation | 27 (2.6) |
| Non-CRLF2 | 98 (9.6) |
| ABL1-class fusions | 2 (0.2) |
| JAK2-R | 2 (0.2) |
| EPOR-R | 0 |
| NTRK3-R | 1 (0.1) |
| Other JAK-STAT | 2 (0.2) |
| Ras | 6 (0.6) |
| No kinase identified | 56 (5.5) |
| Not tested | 29 (2.8) |
ABL1-class: ZMIZ1-ABL1, EBF1-PDGFRB. JAK2-R: ETV6-JAK2, PAX5-JAK2. NTRK3: ETV6-NTRK3. Other JAK-STAT: IL7R. Ras: KRAS, NRAS.