Table 1. Prediction of relapse using... | American Society of Hematology

Table 1.

Prediction of relapse using different ADAMTS13-related biomarkers at different points of disease activity

Biomarker	Measured at beginning of acute episode	Measured at clinical response	Measured in remission
ADAMTS13 activity <10%	Diagnostic of TTP	Predictor of relapse	Predictor of relapse^38,57,58
ADAMTS13 Ag	No association⁸¹	Higher levels associated with sustained remission⁸²	Associated with relapse vs no association⁵⁸
ADAMTS13 inhibitor	No association⁸¹	No association	Associated with relapse
Anti-ADAMTS13 Ab	IgG associated with relapse		IgG³⁹ associated with relapse (IgG4)
VWF Ag	No association	No association	No association

Biomarker	Measured at beginning of acute episode	Measured at clinical response	Measured in remission
ADAMTS13 activity <10%	Diagnostic of TTP	Predictor of relapse	Predictor of relapse^38,57,58
ADAMTS13 Ag	No association⁸¹	Higher levels associated with sustained remission⁸²	Associated with relapse vs no association⁵⁸
ADAMTS13 inhibitor	No association⁸¹	No association	Associated with relapse
Anti-ADAMTS13 Ab	IgG associated with relapse		IgG³⁹ associated with relapse (IgG4)
VWF Ag	No association	No association	No association

Ab, antibody; Ag, antigen.