Patient characteristics
| Patient . | Exposure to heparin during central line placement and daily flushes . | Stem cell collection performed with heparin . | Heparin-PF4 antibody (OD) . | SRA (% release with 0.1 IU/mL UFH) . | Platelet level at time of central line placement (×109/L) . | Platelet level at completion of stem cell collection (×109/L) . | Platelet nadir after stem cell collection and before melphalan (×109/L) . | Thrombosis detected on imaging . | HDM/SCT treatment completed . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Yes | Yes | 3.1 | Positive (100) | 198 | 14 | 10 | Internal jugular | No* |
| 2 | Yes | Yes | 0.5 | Positive (82) | 298 | 36 | 35 | No | Yes |
| 3 | Yes | Yes | 3.3 | Positive (100) | 213 | 27 | 24 | No | No* |
| 4 | Yes | No | 1.95 | Positive (99) | 309 | 84 | 69 | Aortoiliac and femoral artery | Yes |
| 5 | Yes | No | 2.7 | Positive (96) | 248 | 51 | 51 | No | Yes |
| Patient . | Exposure to heparin during central line placement and daily flushes . | Stem cell collection performed with heparin . | Heparin-PF4 antibody (OD) . | SRA (% release with 0.1 IU/mL UFH) . | Platelet level at time of central line placement (×109/L) . | Platelet level at completion of stem cell collection (×109/L) . | Platelet nadir after stem cell collection and before melphalan (×109/L) . | Thrombosis detected on imaging . | HDM/SCT treatment completed . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Yes | Yes | 3.1 | Positive (100) | 198 | 14 | 10 | Internal jugular | No* |
| 2 | Yes | Yes | 0.5 | Positive (82) | 298 | 36 | 35 | No | Yes |
| 3 | Yes | Yes | 3.3 | Positive (100) | 213 | 27 | 24 | No | No* |
| 4 | Yes | No | 1.95 | Positive (99) | 309 | 84 | 69 | Aortoiliac and femoral artery | Yes |
| 5 | Yes | No | 2.7 | Positive (96) | 248 | 51 | 51 | No | Yes |
Stem cells were not reinfused.
OD, optical density; UFH, unfractionated heparin.