Thromboembolic outcomes and death at 12 months
| Patients presenting at least 1 event . | N = 3032 . | |
|---|---|---|
| No. (%) . | 95% CI . | |
| Any thromboembolic event* | 397 (13.8) | 12.6; 15.0 |
| Venous thromboembolism | 378 (13.1) | 12.0; 14.3 |
| Any pulmonary embolism | 142 (5.0) | 4.3; 5.9 |
| Symptomatic | 87 (3.1) | 2.5; 3.9 |
| Fatal | 37 (1.3) | — |
| Incidental (asymptomatic) | 58 (2.0) | 1.6; 2.5 |
| Lower-extremity deep-vein thrombosis | 106 (3.7) | 3.1; 4.4 |
| Proximal | 72 | |
| Distal | 34 | |
| Upper-extremity deep-vein thrombosis | 119 (4.1) | 3.4; 4.8 |
| Superficial-vein thrombosis | 52 (1.8) | 1.3; 2.3 |
| Lower-extremity | 19 (0.7) | 0.4; 1.0 |
| Upper-extremity | 33 (1.1) | 0.8; 1.5 |
| Other venous thromboembolic event | 9 (0.3) | 0.2; 0.6 |
| Arterial thromboembolism | 25 (0.9) | 0.6; 1.3 |
| Stroke or transient ischemic attack† | 18 (0.6) | 0.4; 1.1 |
| Acute myocardial infarction‡ | 4 (0.14) | 0.06; 0.34 |
| Acute lower-limb ischemia | 3 (0.10) | 0.03; 0.29 |
| Catheter-related thrombosis | 111 (3.8) | 3.2; 4.5 |
| Upper-extremity deep-vein thrombosis | 106 (3.8) | — |
| Pulmonary embolism associated with upper-extremity deep-vein thrombosis§ | 5 (0.2) | — |
| Venous thromboembolism excluding catheter-related upper-extremity deep-vein thrombosis|| | 276 (9.6) | 8.7; 10.7 |
| Death | 656 (24.6) | 22.9; 26.3 |
| Patients presenting at least 1 event . | N = 3032 . | |
|---|---|---|
| No. (%) . | 95% CI . | |
| Any thromboembolic event* | 397 (13.8) | 12.6; 15.0 |
| Venous thromboembolism | 378 (13.1) | 12.0; 14.3 |
| Any pulmonary embolism | 142 (5.0) | 4.3; 5.9 |
| Symptomatic | 87 (3.1) | 2.5; 3.9 |
| Fatal | 37 (1.3) | — |
| Incidental (asymptomatic) | 58 (2.0) | 1.6; 2.5 |
| Lower-extremity deep-vein thrombosis | 106 (3.7) | 3.1; 4.4 |
| Proximal | 72 | |
| Distal | 34 | |
| Upper-extremity deep-vein thrombosis | 119 (4.1) | 3.4; 4.8 |
| Superficial-vein thrombosis | 52 (1.8) | 1.3; 2.3 |
| Lower-extremity | 19 (0.7) | 0.4; 1.0 |
| Upper-extremity | 33 (1.1) | 0.8; 1.5 |
| Other venous thromboembolic event | 9 (0.3) | 0.2; 0.6 |
| Arterial thromboembolism | 25 (0.9) | 0.6; 1.3 |
| Stroke or transient ischemic attack† | 18 (0.6) | 0.4; 1.1 |
| Acute myocardial infarction‡ | 4 (0.14) | 0.06; 0.34 |
| Acute lower-limb ischemia | 3 (0.10) | 0.03; 0.29 |
| Catheter-related thrombosis | 111 (3.8) | 3.2; 4.5 |
| Upper-extremity deep-vein thrombosis | 106 (3.8) | — |
| Pulmonary embolism associated with upper-extremity deep-vein thrombosis§ | 5 (0.2) | — |
| Venous thromboembolism excluding catheter-related upper-extremity deep-vein thrombosis|| | 276 (9.6) | 8.7; 10.7 |
| Death | 656 (24.6) | 22.9; 26.3 |
All time-to-event outcomes were estimated by a competitive risk analysis taking into account the competing risk of death. Mortality was estimated by the Kaplan-Meier method.
Some patients experienced >1 event. Other venous thromboembolic events were located as follows: 4 in the portal vein, 2 in the inferior vena cava, 1 in the renal and splanchnic veins, 1 in the splanchnic vein, and 1 in the mesenteric vein.
Four strokes were fatal.
One was fatal.
None was fatal.
Nine patients experienced both a catheter-related thrombotic event and a venous thromboembolic event unrelated to the catheter.