Number of clonal expansions without intraclonal diversity grouped by donor and B-cell subset
| Donors (n) . | B-cell subset . | No. of clonal expansions . | Individuals with clonal expansions . | Somatically mutated IGH VDJ gene clones* . | Average no. of clones per individual (95% CI) . |
|---|---|---|---|---|---|
| Healthy individuals (7) | Naive | 0 | 0/7 | n.a. | n.d. |
| CD5+ | 0 | 0/7 | n.a. | n.d. | |
| CSM | 0 | 0/7 | n.a. | 0 (0.00-0.00) | |
| NCSM | 1 | 1/7 | 1 | 0.14 (0.00-0.43) | |
| HCV+ patients (22) | Naive | 0 | 0/22 | n.a. | n.d. |
| CD5+ | 3 | 2/22 | 0 | n.d. | |
| CSM | 8 | 3/22 | 8 | 0.36 (0.00-0.95) | |
| NCSM | 41 | 12/22 | 28 | 1.86 (0.91-3.14) |
| Donors (n) . | B-cell subset . | No. of clonal expansions . | Individuals with clonal expansions . | Somatically mutated IGH VDJ gene clones* . | Average no. of clones per individual (95% CI) . |
|---|---|---|---|---|---|
| Healthy individuals (7) | Naive | 0 | 0/7 | n.a. | n.d. |
| CD5+ | 0 | 0/7 | n.a. | n.d. | |
| CSM | 0 | 0/7 | n.a. | 0 (0.00-0.00) | |
| NCSM | 1 | 1/7 | 1 | 0.14 (0.00-0.43) | |
| HCV+ patients (22) | Naive | 0 | 0/22 | n.a. | n.d. |
| CD5+ | 3 | 2/22 | 0 | n.d. | |
| CSM | 8 | 3/22 | 8 | 0.36 (0.00-0.95) | |
| NCSM | 41 | 12/22 | 28 | 1.86 (0.91-3.14) |
We defined a clonal rearrangement as mutated when the mutation frequency was ≥1%.