Table 1. Human CLL patient information... | American Society of Hematology

Table 1.

Human CLL patient information

Patient no.	Age, y	Treated	CD38⁺	Zap70⁺	IgVH mutation	Cytogenetics	WBC, × 10⁹/L
UK hCLL
1	76	No	Positive		U-CLL	Trisomy 12	19.8
2	82	No	Negative	Negative	M-CLL		20.7
3	56	No			U-CLL
4	36	No	Negative		M-CLL	13q deletion	38.3
6	46	No	Negative	Negative	M-CLL	13q deletion	41
7	52	Yes			M-CLL		15.2
8	69	No	Positive		M-CLL	Normal	29
9	57	Yes			U-CLL		40
10	62	Yes			M-CLL	11.7% 17p deleted cells	83.7
11	69	No			M-CLL	Trisomy 12, 13q deletion	30.2
13	70	No			M-CLL		17.4
14	63	No	Positive	Positive	M-CLL	Trisomy 12	34.8
15	53	Yes	Positive	Positive	U-CLL	13q deletion	12.1
16	55	Yes			M-CLL		6
17	76	Yes			M-CLL		36.6
18	80	Yes			U-CLL		142
20	57	No			U-CLL		7.4
21	78	No			M-CLL		45.9
22	74	No	Negative	Negative	M-CLL		11.3
23	77	Yes*	Negative	Negative	M-CLL		11
24	71	No	Negative	Negative	M-CLL		7.7
25	70	No	Negative	Negative	M-CLL		23
26	62	No	Negative	Positive	M-CLL		62.5
27	64	No	Negative	Positive	U-CLL		9.4
28	58	Yes*	Negative	Positive	U-CLL		8.4
29	80	Yes*	Positive	Positive	U-CLL		39.6
30	52	No	Negative	Positive	U-CLL		68.2
31	66	No	Negative	Negative	U-CLL		20.4
OSU hCLL
1	40				M-CLL	13q deletion	88.2
2	59				M-CLL	13q deletion	22.6
3					M-CLL	13q deletion	99.1
4	51				M-CLL	Trisomy 12	148.8
5	71				U-CLL		138
6					U-CLL	17p deletion; 13q deletion	152
7					U-CLL	13q deletion; 11q deletion	196.6
8	57				U-CLL	13q deletion; 2.5% trisomy 12	38.2
9					M-CLL		106.9
10					M-CLL	13q deletion	221.3
11	61				M-CLL		78.2
12	68				M-CLL	13q deletion	170.9
13	72				U-CLL	Trisomy 12	135.2
14	61				U-CLL	17p deletion; 13q deletion	87
15	55				U-CLL		157.2
16	67				U-CLL	Trisomy 12	330.7

Patient no.	Age, y	Treated	CD38⁺	Zap70⁺	IgVH mutation	Cytogenetics	WBC, × 10⁹/L
UK hCLL
1	76	No	Positive		U-CLL	Trisomy 12	19.8
2	82	No	Negative	Negative	M-CLL		20.7
3	56	No			U-CLL
4	36	No	Negative		M-CLL	13q deletion	38.3
6	46	No	Negative	Negative	M-CLL	13q deletion	41
7	52	Yes			M-CLL		15.2
8	69	No	Positive		M-CLL	Normal	29
9	57	Yes			U-CLL		40
10	62	Yes			M-CLL	11.7% 17p deleted cells	83.7
11	69	No			M-CLL	Trisomy 12, 13q deletion	30.2
13	70	No			M-CLL		17.4
14	63	No	Positive	Positive	M-CLL	Trisomy 12	34.8
15	53	Yes	Positive	Positive	U-CLL	13q deletion	12.1
16	55	Yes			M-CLL		6
17	76	Yes			M-CLL		36.6
18	80	Yes			U-CLL		142
20	57	No			U-CLL		7.4
21	78	No			M-CLL		45.9
22	74	No	Negative	Negative	M-CLL		11.3
23	77	Yes*	Negative	Negative	M-CLL		11
24	71	No	Negative	Negative	M-CLL		7.7
25	70	No	Negative	Negative	M-CLL		23
26	62	No	Negative	Positive	M-CLL		62.5
27	64	No	Negative	Positive	U-CLL		9.4
28	58	Yes*	Negative	Positive	U-CLL		8.4
29	80	Yes*	Positive	Positive	U-CLL		39.6
30	52	No	Negative	Positive	U-CLL		68.2
31	66	No	Negative	Negative	U-CLL		20.4
OSU hCLL
1	40				M-CLL	13q deletion	88.2
2	59				M-CLL	13q deletion	22.6
3					M-CLL	13q deletion	99.1
4	51				M-CLL	Trisomy 12	148.8
5	71				U-CLL		138
6					U-CLL	17p deletion; 13q deletion	152
7					U-CLL	13q deletion; 11q deletion	196.6
8	57				U-CLL	13q deletion; 2.5% trisomy 12	38.2
9					M-CLL		106.9
10					M-CLL	13q deletion	221.3
11	61				M-CLL		78.2
12	68				M-CLL	13q deletion	170.9
13	72				U-CLL	Trisomy 12	135.2
14	61				U-CLL	17p deletion; 13q deletion	87
15	55				U-CLL		157.2
16	67				U-CLL	Trisomy 12	330.7

Blank cells indicate that relevant information is not available. Total peripheral white blood cell (WBC) counts at the time of collection are indicated. Cytogenetics, CD38⁺, Zap70⁺ are indicated if known through previous diagnosis or by flow cytometry. CD38⁺ distinction was determined by >30% CD38⁺ cells of leukemic clone.^23,58 Patient samples were collected at the University of Kentucky Markey Cancer Center (UK hCLL) or as indicated at The Ohio State (OSU hCLL) Brown Comprehensive Cancer Center.

Patient has received previous therapy but not on current treatment.

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