Table 2 List of secondary mutations... | American Society of Hematology

Table 2

List of secondary mutations occurring in CMP6-selected TS1 subclones derived from 6 different GF-independent TS1 clones

TS1 clones	Primary mutation		Secondary mutation		Frequency
TS1 clones	JAK1	JAK3	JAK1	JAK3	Frequency
A3	Y652H	—	—	Y904H	7/10
			—	Y904C	1/10
			—	—	2/10
A4	Y652H	—	—	R840C	1/10
			—	Y904H	1/10
			—	Y904C	6/10
			—	—	2/10
A6	—	L586S	F958C	—	3/6
A6	—	L586S	F958V	—	3/6
A11	—	V674A	Y652H	—	1/27
			F958C	—	4/27
			F958V	—	1/27
			F958L	—	1/27
			—	—	20/27
T4	—	V674A	F958C	—	10/13
T4	—	V674A	F958V	—	3/13
T15	—	T848A	Y652H	—	4/10
			F804L	—	1/10
			F958C	—	1/10
			—	—	4/10

TS1 clones	Primary mutation		Secondary mutation		Frequency
TS1 clones	JAK1	JAK3	JAK1	JAK3	Frequency
A3	Y652H	—	—	Y904H	7/10
			—	Y904C	1/10
			—	—	2/10
A4	Y652H	—	—	R840C	1/10
			—	Y904H	1/10
			—	Y904C	6/10
			—	—	2/10
A6	—	L586S	F958C	—	3/6
A6	—	L586S	F958V	—	3/6
A11	—	V674A	Y652H	—	1/27
			F958C	—	4/27
			F958V	—	1/27
			F958L	—	1/27
			—	—	20/27
T4	—	V674A	F958C	—	10/13
T4	—	V674A	F958V	—	3/13
T15	—	T848A	Y652H	—	4/10
			F804L	—	1/10
			F958C	—	1/10
			—	—	4/10

The autonomous TS1 clones with their corresponding primary JAK mutation and the secondary mutations identified in their CMP6-selected subclones. For each combination, relative frequency is indicated.

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