Cell growth-inhibitory profile of FF-10101 and quizartinib
| Cell lines . | GI50, nM . | |
|---|---|---|
| FF-10101 . | Quizartinib . | |
| MV4-11 | 0.83 | 0.95 |
| MOLM-13 | 1.1 | 1.6 |
| MOLM-14 | 1.5 | 2.4 |
| Kasumi-1 | 26 | 16 |
| EOL-1 | 72 | 0.46 |
| THP-1 | >1000 | >1000 |
| K562 | >1000 | >1000 |
| Cell lines . | GI50, nM . | |
|---|---|---|
| FF-10101 . | Quizartinib . | |
| MV4-11 | 0.83 | 0.95 |
| MOLM-13 | 1.1 | 1.6 |
| MOLM-14 | 1.5 | 2.4 |
| Kasumi-1 | 26 | 16 |
| EOL-1 | 72 | 0.46 |
| THP-1 | >1000 | >1000 |
| K562 | >1000 | >1000 |
Mean GI50 values from 3 independent experiments are indicated in the table. Leukemia cell lines were incubated with various concentrations of FLT3 inhibitors at 37°C for 2 d followed by determination of GI50 values.