Table 2.

Goals for frailty assessment and treatment among patients with blood cancer

Goals and approach
1. Screen for frailty 
  a. Refer to geriatrician, if appropriate 
  b. Even if robust, repeat screen(s) after treatment of disease progression 
2. Tailor treatment goals 
  a. Assess and frequently reassess goals 
  b. Integrate frailty-specific treatment data when available 
  c. Balance potential for longer life and/or cure with treatment toxicity, visit burden, and potential for hospitalization 
3. Improve strength and address exhaustion 
  a. PT and/or OT 
  b. Consider medication side effects 
  c. Judicious use of transfusions and/or ESAs (MDS) 
  d. Evaluate for mood disorders 
4. Address weight loss 
  a. Nutritionist evaluation 
  b. Socialized meals 
  c. Food access (eg, Meals on Wheels) 
  d. Replace/fix dentures 
  e. Liberalize diet (beware of transplant or neutropenic diet) 
5. Reduce polypharmacy 
  a. Frequent medication reconciliation 
  b. Review evolving medication plans of other providers 
  c. “Start low and go slow” with new medications 
  d. Frequently assess for side effects 
6. Screen for and address social support 
  a. Obtain contact information for all caregivers 
  b. Establish surrogate or health care power of attorney 
  c. Assess for loneliness 
  d. Assess for caregiver burnout 
  e. Evaluate for financial strain and refer to social work, if appropriate 
7. Screen for and address cognitive impairment 
  a. Administer validated assessment tool 
  b. Anticipate potential cognitive decompensation when hospitalized 
  c. Consider role of pharmacotherapy 
Goals and approach
1. Screen for frailty 
  a. Refer to geriatrician, if appropriate 
  b. Even if robust, repeat screen(s) after treatment of disease progression 
2. Tailor treatment goals 
  a. Assess and frequently reassess goals 
  b. Integrate frailty-specific treatment data when available 
  c. Balance potential for longer life and/or cure with treatment toxicity, visit burden, and potential for hospitalization 
3. Improve strength and address exhaustion 
  a. PT and/or OT 
  b. Consider medication side effects 
  c. Judicious use of transfusions and/or ESAs (MDS) 
  d. Evaluate for mood disorders 
4. Address weight loss 
  a. Nutritionist evaluation 
  b. Socialized meals 
  c. Food access (eg, Meals on Wheels) 
  d. Replace/fix dentures 
  e. Liberalize diet (beware of transplant or neutropenic diet) 
5. Reduce polypharmacy 
  a. Frequent medication reconciliation 
  b. Review evolving medication plans of other providers 
  c. “Start low and go slow” with new medications 
  d. Frequently assess for side effects 
6. Screen for and address social support 
  a. Obtain contact information for all caregivers 
  b. Establish surrogate or health care power of attorney 
  c. Assess for loneliness 
  d. Assess for caregiver burnout 
  e. Evaluate for financial strain and refer to social work, if appropriate 
7. Screen for and address cognitive impairment 
  a. Administer validated assessment tool 
  b. Anticipate potential cognitive decompensation when hospitalized 
  c. Consider role of pharmacotherapy 

ESA, erythropoiesis-stimulating agents; OT, occupational therapy; PT, physical therapy. Adapted with permission from Huisingh-Scheetz and Walston.69 

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