Levels of dFLC and markers of organ involvement in patients who required second-line therapy
| Variables . | Baseline median (IQR) . | Best response median (IQR) . | Second-line therapy initiation median (IQR) . |
|---|---|---|---|
| dFLC, mg/L (92 patients) | 140 (59-324) | 12 (5-31) | 55 (26-108) |
| NT-proBNP, ng/L (56 patients with heart involvement) | 2913 (1329-5577) | 1419 (724-4107) | 1602 (958-5443) |
| Proteinuria, g/24 h (61 patients with renal involvement) | 5.2 (2.5-7.5) | 2.7 (1.3-4.9) | 2.4 (0.7-4.5) |
| eGFR, mL/min per 1.73 m2 (61 patients with renal involvement) | 72 (49-87) | 79 (42 to >90) | 46 (32-75) |
| Variables . | Baseline median (IQR) . | Best response median (IQR) . | Second-line therapy initiation median (IQR) . |
|---|---|---|---|
| dFLC, mg/L (92 patients) | 140 (59-324) | 12 (5-31) | 55 (26-108) |
| NT-proBNP, ng/L (56 patients with heart involvement) | 2913 (1329-5577) | 1419 (724-4107) | 1602 (958-5443) |
| Proteinuria, g/24 h (61 patients with renal involvement) | 5.2 (2.5-7.5) | 2.7 (1.3-4.9) | 2.4 (0.7-4.5) |
| eGFR, mL/min per 1.73 m2 (61 patients with renal involvement) | 72 (49-87) | 79 (42 to >90) | 46 (32-75) |
Baseline values were measured at the time of diagnosis. Best response was achieved after a median of 5.8 mo from up-front therapy initiation.