Multivariate analysis for OS using the parameters TP53 expression, Ki67 index, and MIPI score
| Variable and comparison . | P . | HR . | 95% confidence interval . | Events overall . |
|---|---|---|---|---|
| TP53 | ||||
| Negative vs low | .21 | 1.43 | 0.82-2.51 | 118/348 |
| Intermediate vs low | .88 | 1.04 | 0.64-1.67 | |
| High vs low | <.0001 | 3.01 | 1.87-4.83 | |
| TP53 | ||||
| Negative vs low | .19 | 1.52 | 0.81-2.87 | 96/276 |
| Intermediate vs low | .58 | 0.86 | 0.50-1.47 | |
| High vs low | .0043 | 2.20 | 1.28-3.78 | |
| Ki-67index | ||||
| +10% | .0002 | 1.20 | 1.09-1.32 | |
| TP53 | ||||
| Negative vs low | .17 | 1.56 | 0.82-2.94 | 96/276 |
| Intermediate vs low | .28 | 0.74 | 0.43-1.27 | |
| High vs low | .0068 | 2.09 | 1.23-3.55 | |
| Ki-67 index | ||||
| +10% | .012 | 1.13 | 1.03-1.25 | |
| MIPI score | ||||
| 1 | <.0001 | 2.00 | 1.46-2.74 |
| Variable and comparison . | P . | HR . | 95% confidence interval . | Events overall . |
|---|---|---|---|---|
| TP53 | ||||
| Negative vs low | .21 | 1.43 | 0.82-2.51 | 118/348 |
| Intermediate vs low | .88 | 1.04 | 0.64-1.67 | |
| High vs low | <.0001 | 3.01 | 1.87-4.83 | |
| TP53 | ||||
| Negative vs low | .19 | 1.52 | 0.81-2.87 | 96/276 |
| Intermediate vs low | .58 | 0.86 | 0.50-1.47 | |
| High vs low | .0043 | 2.20 | 1.28-3.78 | |
| Ki-67index | ||||
| +10% | .0002 | 1.20 | 1.09-1.32 | |
| TP53 | ||||
| Negative vs low | .17 | 1.56 | 0.82-2.94 | 96/276 |
| Intermediate vs low | .28 | 0.74 | 0.43-1.27 | |
| High vs low | .0068 | 2.09 | 1.23-3.55 | |
| Ki-67 index | ||||
| +10% | .012 | 1.13 | 1.03-1.25 | |
| MIPI score | ||||
| 1 | <.0001 | 2.00 | 1.46-2.74 |