Examples of the concepts generated in animal models
| Concepts generated . |
|---|
| Established clinical procedures |
| BMT |
| GVL |
| T-cell depletion |
| Peritransplant immune suppression |
| Donor lymphocyte infusions |
| RIC |
| TLI-based conditioning |
| Posttransplant cyclophosphamide |
| Promising concepts under investigation |
| Treg expansion (eg, adoptive transfer, IL-2, HDAC inhibition, demethylating agents) |
| Naïve T-cell depletion |
| Alternative alloreactive T-cell depletion strategies (eg, bortezomib) |
| Cytokine inhibition (eg, IL-6, IL-12, IL-21) |
| Chemokine blockade (CCR5) |
| CAR-expressing donor lymphocyte infusions |
| Costimulation blockade |
| Manipulation of microbiota |
| Concepts generated . |
|---|
| Established clinical procedures |
| BMT |
| GVL |
| T-cell depletion |
| Peritransplant immune suppression |
| Donor lymphocyte infusions |
| RIC |
| TLI-based conditioning |
| Posttransplant cyclophosphamide |
| Promising concepts under investigation |
| Treg expansion (eg, adoptive transfer, IL-2, HDAC inhibition, demethylating agents) |
| Naïve T-cell depletion |
| Alternative alloreactive T-cell depletion strategies (eg, bortezomib) |
| Cytokine inhibition (eg, IL-6, IL-12, IL-21) |
| Chemokine blockade (CCR5) |
| CAR-expressing donor lymphocyte infusions |
| Costimulation blockade |
| Manipulation of microbiota |
CAR, chimeric antigen receptor; TLI, total lymphoid irradiation.