Top enriched annotations of target genes near human Tfh active enhancers
| Top enriched phenotypes . | Binomial FDR Q value . |
|---|---|
| Abnormal bone marrow cell morphology/development | 0 |
| Abnormal lymphocyte morphology | 0 |
| Decreased hematopoietic cell number | 1.46E-317 |
| Abnormal lymphocyte cell number | 5.19E-303 |
| Abnormal lymphocyte physiology | 3.03E-294 |
| Abnormal leukopoiesis | 7.28E-289 |
| Abnormal mononuclear cell differentiation | 1.66E-286 |
| Abnormal myeloblast morphology/development | 9.13E-286 |
| Abnormal lymphopoiesis | 2.51E-283 |
| Decreased leukocyte cell number | 8.16E-282 |
| Abnormal T-cell morphology | 2.85E-281 |
| Increased hematopoietic cell number | 3.07E-258 |
| Decreased lymphocyte cell number | 9.68E-258 |
| Abnormal T-cell differentiation | 3.37E-250 |
| Abnormal immune serum protein physiology | 5.79E-250 |
| Increased leukocyte cell number | 1.30E-240 |
| Abnormal T-cell number | 1.17E-235 |
| Abnormal T-cell physiology | 5.65E-232 |
| Increased lymphocyte cell number | 1.07E-212 |
| Abnormal B-cell morphology | 1.37E-201 |
| Top enriched phenotypes . | Binomial FDR Q value . |
|---|---|
| Abnormal bone marrow cell morphology/development | 0 |
| Abnormal lymphocyte morphology | 0 |
| Decreased hematopoietic cell number | 1.46E-317 |
| Abnormal lymphocyte cell number | 5.19E-303 |
| Abnormal lymphocyte physiology | 3.03E-294 |
| Abnormal leukopoiesis | 7.28E-289 |
| Abnormal mononuclear cell differentiation | 1.66E-286 |
| Abnormal myeloblast morphology/development | 9.13E-286 |
| Abnormal lymphopoiesis | 2.51E-283 |
| Decreased leukocyte cell number | 8.16E-282 |
| Abnormal T-cell morphology | 2.85E-281 |
| Increased hematopoietic cell number | 3.07E-258 |
| Decreased lymphocyte cell number | 9.68E-258 |
| Abnormal T-cell differentiation | 3.37E-250 |
| Abnormal immune serum protein physiology | 5.79E-250 |
| Increased leukocyte cell number | 1.30E-240 |
| Abnormal T-cell number | 1.17E-235 |
| Abnormal T-cell physiology | 5.65E-232 |
| Increased lymphocyte cell number | 1.07E-212 |
| Abnormal B-cell morphology | 1.37E-201 |
Unsupervised enrichment analysis of annotated genes in the proximity of candidate enhancer regions identified by active Tfh cell enhancers. The top enriched Mouse Genome Informatics phenotype ontology terms showing highly significant enrichment of genes implicated in immune cell-related phenotypes are shown. Only terms that showed significant enrichment and had a binomial-fold enrichment of ≥2 were considered.