IV iron preparations
| . | Preparations . | |||||
|---|---|---|---|---|---|---|
| Generic name | Iron sucrose | Sodium ferric gluconate | LMW iron dextran | Ferumoxytol | FCM | Iron isomaltoside |
| Trade (brand) name | Venofer | Ferrlecit | INFeD, CosmoFer | Feraheme | Ferinject, Injectafer, | Monofer (Europe only) |
| Manufacturer | American Regent Inc | Sanofi Aventis Inc | Watson Pharma | AMAG Pharmaceuticals | Luitpold Pharmaceuticals | Pharmacosmos |
| Carbohydrate | Sucrose | Gluconate | LMW iron dextran | Polyglucose sorbitol carboxymethylether | Carboxymaltose | Isomaltoside |
| Concentration of elemental iron | 20 mg/mL | 12.5 mg/mL | 50 mg/mL | 30 mg/mL | 50 mg/mL | 100 mg/mL |
| TDI | No | No | Yes | No | Yes | Yes |
| Test dose required | No | No | Yes | No | No | No |
| Recommended max dose | Multiple doses of 200-300 mg | Multiple doses of 125-187.5 mg | Multiple doses of 100 mg or single infusion of 1000 mg | 2 infusions of 510 mg given 3-8 d apart or a single dose of 1020 mg | 2 doses of 750 mg, given 7 or more days apart (weight <50 kg) | A single infusion, at a dose of 20 mg/kg (or 1000 mg) or up to 3 doses of 500 mg given over 7 d |
| 2 doses of 15 mg/kg (or 1000 mg) given 7 or more days apart if weight >50 kg | ||||||
| Infusion time | Over a period of at least 15 min | 1 h | 1 h | 15 min | 15 min | 15 min |
| Pregnancy category | B | B | C | C | C | Not listed |
| . | Preparations . | |||||
|---|---|---|---|---|---|---|
| Generic name | Iron sucrose | Sodium ferric gluconate | LMW iron dextran | Ferumoxytol | FCM | Iron isomaltoside |
| Trade (brand) name | Venofer | Ferrlecit | INFeD, CosmoFer | Feraheme | Ferinject, Injectafer, | Monofer (Europe only) |
| Manufacturer | American Regent Inc | Sanofi Aventis Inc | Watson Pharma | AMAG Pharmaceuticals | Luitpold Pharmaceuticals | Pharmacosmos |
| Carbohydrate | Sucrose | Gluconate | LMW iron dextran | Polyglucose sorbitol carboxymethylether | Carboxymaltose | Isomaltoside |
| Concentration of elemental iron | 20 mg/mL | 12.5 mg/mL | 50 mg/mL | 30 mg/mL | 50 mg/mL | 100 mg/mL |
| TDI | No | No | Yes | No | Yes | Yes |
| Test dose required | No | No | Yes | No | No | No |
| Recommended max dose | Multiple doses of 200-300 mg | Multiple doses of 125-187.5 mg | Multiple doses of 100 mg or single infusion of 1000 mg | 2 infusions of 510 mg given 3-8 d apart or a single dose of 1020 mg | 2 doses of 750 mg, given 7 or more days apart (weight <50 kg) | A single infusion, at a dose of 20 mg/kg (or 1000 mg) or up to 3 doses of 500 mg given over 7 d |
| 2 doses of 15 mg/kg (or 1000 mg) given 7 or more days apart if weight >50 kg | ||||||
| Infusion time | Over a period of at least 15 min | 1 h | 1 h | 15 min | 15 min | 15 min |
| Pregnancy category | B | B | C | C | C | Not listed |
FDA pregnancy categories: B, Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. C, Animal reproductive studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
TDI, total dose infusion.