Infectious complications after rituximab therapy for ITP
| Sex, age (y) . | Duration of ITP (mo) . | Splenectomy before rituximab treatment . | Site of infection . | Infectious agents . | Delay after first rituximab infusion, months . | Admission to hospital/parenteral antibiotics . | Current treatment with steroids . | Last gammaglobulin level (g/L) . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|
| F, 38 | 16 | No | Pulmonary | ND | 2 | −/+ | No | NA | Recovery |
| M, 67 | 2 | No | Cutaneous | ND | 2 | −/+ | No | 12.4 | Recovery |
| F, 37 | 2 | No | Pulmonary | Streptococcus pneumoniae | 18 | +/+ | No | 10.2 | Recovery |
| M, 71 | 119 | No | Flu-like syndrome | ND | 4 | −/− | No | NA | Recovery |
| M, 73 | 1 | No | Bone, septic shock | Aureus Staphylococcus | 13 | +/+ | Yes | NA | Death |
| M, 70 | 19 | Yes | Pulmonary | Enterococcus faecium | 12 | +/+ | Yes | 5.4 | Death |
| F, 74 | 2 | No | Urinary tract | Escherichia coli | 1 | +/+ | Yes | 6.2 | Recovery |
| Sinus | Aspergillus fumigatus | 2 | −/+ | Yes | 6.2 | Recovery | |||
| Pulmonary | ND | 2.5 | −/+ | Yes | 6.4 | Recovery | |||
| Urinary tract | Streptococcus, group D | 4 | −/+ | Yes | NA | Recovery | |||
| Septic shock | Enterobacter cloacae | 14 | +/+ | Yes | NA | Death |
| Sex, age (y) . | Duration of ITP (mo) . | Splenectomy before rituximab treatment . | Site of infection . | Infectious agents . | Delay after first rituximab infusion, months . | Admission to hospital/parenteral antibiotics . | Current treatment with steroids . | Last gammaglobulin level (g/L) . | Outcome . |
|---|---|---|---|---|---|---|---|---|---|
| F, 38 | 16 | No | Pulmonary | ND | 2 | −/+ | No | NA | Recovery |
| M, 67 | 2 | No | Cutaneous | ND | 2 | −/+ | No | 12.4 | Recovery |
| F, 37 | 2 | No | Pulmonary | Streptococcus pneumoniae | 18 | +/+ | No | 10.2 | Recovery |
| M, 71 | 119 | No | Flu-like syndrome | ND | 4 | −/− | No | NA | Recovery |
| M, 73 | 1 | No | Bone, septic shock | Aureus Staphylococcus | 13 | +/+ | Yes | NA | Death |
| M, 70 | 19 | Yes | Pulmonary | Enterococcus faecium | 12 | +/+ | Yes | 5.4 | Death |
| F, 74 | 2 | No | Urinary tract | Escherichia coli | 1 | +/+ | Yes | 6.2 | Recovery |
| Sinus | Aspergillus fumigatus | 2 | −/+ | Yes | 6.2 | Recovery | |||
| Pulmonary | ND | 2.5 | −/+ | Yes | 6.4 | Recovery | |||
| Urinary tract | Streptococcus, group D | 4 | −/+ | Yes | NA | Recovery | |||
| Septic shock | Enterobacter cloacae | 14 | +/+ | Yes | NA | Death |
NA, not available; ND, not determined.