List of basic questions directed to a subject first investigated for erythrocytosis and during follow-up if PV is eventually diagnosed
| In relation to . | Factors . |
|---|---|
| Personal/medical history | Work exposure, past (resolved) diseases, including neoplasia, surgical interventions, past cardiovascular events and hemorrhage, if menopausal (woman), and altitude (where you live) |
| Family | Relatives with a diagnosis of MPN or suggestive of MPN, with other hematologic neoplasia or disorders; relatives with unexplained erythrocytosis (even vague); and relatives with thrombotic events in unusual sites and/or at an unusual age |
| Lifestyle | Smoking, physical activity, dietary habits, in general, did you modify your lifestyle as we discussed previously?; and nocturnal apnea (ask the spouse) |
| Concomitant comorbidities | Other diseases, in general; and in particular, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and gout |
| Medications | Use of antihypertensive agents, especially diuretics; use of androgens; chronic use of corticosteroids; use of antiplatelet aggregants or anticoagulants and why; and compliance of prescribed medications, any |
| Contraception | Past and current use of contraceptives |
| Pregnancies | Previous pregnancies and outcomes; abortions and/or miscarriages; and planning for future pregnancies |
| Actual symptoms | “Constitutional” symptoms (drenching night sweats, weight loss, unexplained fever >37.5°C); pruritus and characteristics (when, how long, how do you manage it?); vasomotor symptoms (headache, dizziness, tinnitus, acral paresthesias, erythromelalgia, skin reddening, and concentration problems); muscle and joint aches; bone pain; abdominal discomfort, early satiety; and level of tiredness/fatigue and how it affects daily activities |
| In relation to . | Factors . |
|---|---|
| Personal/medical history | Work exposure, past (resolved) diseases, including neoplasia, surgical interventions, past cardiovascular events and hemorrhage, if menopausal (woman), and altitude (where you live) |
| Family | Relatives with a diagnosis of MPN or suggestive of MPN, with other hematologic neoplasia or disorders; relatives with unexplained erythrocytosis (even vague); and relatives with thrombotic events in unusual sites and/or at an unusual age |
| Lifestyle | Smoking, physical activity, dietary habits, in general, did you modify your lifestyle as we discussed previously?; and nocturnal apnea (ask the spouse) |
| Concomitant comorbidities | Other diseases, in general; and in particular, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and gout |
| Medications | Use of antihypertensive agents, especially diuretics; use of androgens; chronic use of corticosteroids; use of antiplatelet aggregants or anticoagulants and why; and compliance of prescribed medications, any |
| Contraception | Past and current use of contraceptives |
| Pregnancies | Previous pregnancies and outcomes; abortions and/or miscarriages; and planning for future pregnancies |
| Actual symptoms | “Constitutional” symptoms (drenching night sweats, weight loss, unexplained fever >37.5°C); pruritus and characteristics (when, how long, how do you manage it?); vasomotor symptoms (headache, dizziness, tinnitus, acral paresthesias, erythromelalgia, skin reddening, and concentration problems); muscle and joint aches; bone pain; abdominal discomfort, early satiety; and level of tiredness/fatigue and how it affects daily activities |