Thrombotic-regulated proteins identified by LC-MS/MS label-free quantitation
| Accession . | SwissProt entry . | Protein description . | Function . | Confidence score . | ANOVA, P . | Fold change . | Regulation . |
|---|---|---|---|---|---|---|---|
| P01857 | IGHG1_HUMAN | Ig γ 1 chain C region | Immune response | 172.7 | .00119 | 2.3 | Up |
| Q6S8J3 | POTEE_HUMAN | POTE ankyrin domain family member E | Cytoskeleton, actin binding | 162.8 | .03278 | 16.2 | Up |
| Q93077 | H2A1C_HUMAN | Histone H2A type 1 C | DNA binding | 131.8 | .00348 | 3.0 | Up |
| P01861 | IGHG4_HUMAN | Ig γ 4 chain C region | Immune response | 124.4 | .00196 | 2.1 | Up |
| Q96KK5 | H2A1H_HUMAN | Histone H2A type 1H | DNA binding | 123.1 | .00586 | 3.0 | Up |
| P31146 | COR1A_HUMAN | Coronin 1A | Cytoskeleton, actin binding | 109.7 | .00079 | 2.7 | Down |
| Q9BYX7 | ACTBM_HUMAN | Putative β-actin-like protein 3 | Cytoskeleton, actin binding | 91.0 | .02461 | 2.4 | Up |
| P01834 | IGKC_HUMAN | Ig κ chain C region | Immune response | 73.7 | .00029 | 3.0 | Up |
| P05120 | PAI2_HUMAN | Plasminogen activator inhibitor 2 | Proteolysis, coagulation | 73.0 | .00006 | 4.1 | Down |
| Q8IUE6 | H2A2B_HUMAN | Histone H2A type 2 B | DNA binding | 72.1 | .00342 | 2.6 | Up |
| PO8238 | HS90B_HUMAN | Heat shock protein HSP 90 β | Immune response | 59.2 | .00008 | 71.0 | Down |
| P31949 | S10AB_HUMAN | Protein S100 A11 | Immune response, signal transduction | 57.4 | .04707 | 3.0 | Up |
| Accession . | SwissProt entry . | Protein description . | Function . | Confidence score . | ANOVA, P . | Fold change . | Regulation . |
|---|---|---|---|---|---|---|---|
| P01857 | IGHG1_HUMAN | Ig γ 1 chain C region | Immune response | 172.7 | .00119 | 2.3 | Up |
| Q6S8J3 | POTEE_HUMAN | POTE ankyrin domain family member E | Cytoskeleton, actin binding | 162.8 | .03278 | 16.2 | Up |
| Q93077 | H2A1C_HUMAN | Histone H2A type 1 C | DNA binding | 131.8 | .00348 | 3.0 | Up |
| P01861 | IGHG4_HUMAN | Ig γ 4 chain C region | Immune response | 124.4 | .00196 | 2.1 | Up |
| Q96KK5 | H2A1H_HUMAN | Histone H2A type 1H | DNA binding | 123.1 | .00586 | 3.0 | Up |
| P31146 | COR1A_HUMAN | Coronin 1A | Cytoskeleton, actin binding | 109.7 | .00079 | 2.7 | Down |
| Q9BYX7 | ACTBM_HUMAN | Putative β-actin-like protein 3 | Cytoskeleton, actin binding | 91.0 | .02461 | 2.4 | Up |
| P01834 | IGKC_HUMAN | Ig κ chain C region | Immune response | 73.7 | .00029 | 3.0 | Up |
| P05120 | PAI2_HUMAN | Plasminogen activator inhibitor 2 | Proteolysis, coagulation | 73.0 | .00006 | 4.1 | Down |
| Q8IUE6 | H2A2B_HUMAN | Histone H2A type 2 B | DNA binding | 72.1 | .00342 | 2.6 | Up |
| PO8238 | HS90B_HUMAN | Heat shock protein HSP 90 β | Immune response | 59.2 | .00008 | 71.0 | Down |
| P31949 | S10AB_HUMAN | Protein S100 A11 | Immune response, signal transduction | 57.4 | .04707 | 3.0 | Up |
The top 12 monocyte proteins identified with a higher degree of confidence are shown. Protein IDs were assigned by Waters ProteinLynx Global server software and values above 95% confidence were considered. The score and peptide data are shown. P values calculated by ANOVA represent differences in the abundance of each protein in the presence of VT or HC IgG. Up and Down indicate the upregulation or downregulation of any given protein in VT IgG compared with HC IgG.
ANOVA, analysis of variance; LC, liquid chromatography; pI, isoelectric point.