Putative functional classification of the common genes identified by GSEA
| Gene ontology term . | No. of genes . | Enrichment score . |
|---|---|---|
| Cell migration | 15 | 2.39 |
| Actin cytoskeleton | 10 | 1.57 |
| Microtubule cytoskeleton | 17 | 1.47 |
| Cell adhesion | 11 | 0.95 |
| Small GTPase regulator | 9 | 0.55 |
| Gene ontology term . | No. of genes . | Enrichment score . |
|---|---|---|
| Cell migration | 15 | 2.39 |
| Actin cytoskeleton | 10 | 1.57 |
| Microtubule cytoskeleton | 17 | 1.47 |
| Cell adhesion | 11 | 0.95 |
| Small GTPase regulator | 9 | 0.55 |
DAVID functional clustering analysis was carried out on the common gene dataset obtained from GSEA of the differentially expressed genes at 24 hours after Erg inhibition in endothelial cells and the up-regulated genes identified in HEK293 cells after Erg overexpression.14 The Enrichment Score—the geometric mean (in −log scale) of P values of genes within a corresponding annotation cluster—is used to rank their biological significance.12
GSEA indicates Gene Set Enrichment Analysis Software; and DAVID, Database for Annotation, Visualization & Integrated Discovery.