Table 1

RAP-536 alleviates anemia in Hbbth1/th1 mice and increases RBC numbers in wild-type mice

GroupRBC (106 cells/µL)Hb (g/dL)Hct (%)MCV (fL)MCH (pg)MCHC (g/dL)Retic (%)RDWa (fL)
Wild type + vehicle 9.2 ± 0.1 13.7 ± 0.1 40.1 ± 0.5 43.5 ± 0.4 14.9 ± 0.1 34.4 ± 0.3 3.1 ± 0.1 28.8 ± 0.3 
Wild type + RAP-536 10.5 ± 0.1* 15.0 ± 0.2* 43.4 ± 0.7* 41.2 ± 0.4† 14.2 ± 0.1* 34.6 ± 0.3 3.1 ± 0.1 28.6 ± 0.2 
Hbbth1/th1 + vehicle 6.3 ± 0.2* 9.0 ± 0.1* 25.3 ± 0.6* 40.2 ± 1.0† 14.4 ± 0.6 35.7 ± 0.7 47.0 ± 5.8* 41.8 ± 1.7* 
Hbbth1/th1 + RAP-536 8.1 ± 0.2‡ 10.4 ± 0.2‡ 30.0 ± 0.7‡ 37.0 ± 0.6§ 12.9 ± 0.4 34.9 ± 0.9 31.3 ± 2.2§ 33.7 ± 1.3 
GroupRBC (106 cells/µL)Hb (g/dL)Hct (%)MCV (fL)MCH (pg)MCHC (g/dL)Retic (%)RDWa (fL)
Wild type + vehicle 9.2 ± 0.1 13.7 ± 0.1 40.1 ± 0.5 43.5 ± 0.4 14.9 ± 0.1 34.4 ± 0.3 3.1 ± 0.1 28.8 ± 0.3 
Wild type + RAP-536 10.5 ± 0.1* 15.0 ± 0.2* 43.4 ± 0.7* 41.2 ± 0.4† 14.2 ± 0.1* 34.6 ± 0.3 3.1 ± 0.1 28.6 ± 0.2 
Hbbth1/th1 + vehicle 6.3 ± 0.2* 9.0 ± 0.1* 25.3 ± 0.6* 40.2 ± 1.0† 14.4 ± 0.6 35.7 ± 0.7 47.0 ± 5.8* 41.8 ± 1.7* 
Hbbth1/th1 + RAP-536 8.1 ± 0.2‡ 10.4 ± 0.2‡ 30.0 ± 0.7‡ 37.0 ± 0.6§ 12.9 ± 0.4 34.9 ± 0.9 31.3 ± 2.2§ 33.7 ± 1.3 

RBC parameters in β-thalassemic (Hbbth1/th1) mice and age-matched C57BL/6 wild-type mice treated with RAP-536 (1 mg/kg, s.c., twice weekly) or vehicle for 2 months starting at 3 months of age. Results are expressed as mean ± SEM (n = 12-17 mice per group). Hb, hemoglobin; Hct, hematocrit; MCV, mean cell volume; MCH, mean cell hemoglobin; MCHC, mean corpuscular hemoglobin concentration; Retic, reticulocytes.

*

P < .001 vs wild type + vehicle.

†

P < .01 vs wild type + vehicle.

‡

P < .001 vs Hbbth1/th1 + vehicle.

§

P < .05 vs Hbbth1/th1 + vehicle.

P < .01 vs Hbbth1/th1 + vehicle.

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