Unconditioned HSCT recommendations and outcomes for different SCID types
| Type of SCID . | MSD/MRD . | Comment . | MUD/MMUD/UCB . | Haplo(T depleted) . | Comment . |
|---|---|---|---|---|---|
| SCID-X1/JAK3 | ✔ | T-cell engraftment; variable recovery of humoral immunity | X | ✔ | For patients younger than 3.5 months, T-cell engraftment; variable recovery of humoral immunity |
| T-B+NK+ | ✔ | T-cell engraftment; recovery of humoral immunity | X | ✔ | For patients younger than 3.5 months, T-cell engraftment; recovery of humoral immunity |
| ADA SCID | ✔ | T-cell engraftment; recovery of humoral immunity | X | X | |
| T-B-NK + (VDJ recombination defects) | X | Poor T-cell recovery; absent humoral recovery; may require repeat HSCT | X | X | |
| Other SCID forms | X | X | X |
| Type of SCID . | MSD/MRD . | Comment . | MUD/MMUD/UCB . | Haplo(T depleted) . | Comment . |
|---|---|---|---|---|---|
| SCID-X1/JAK3 | ✔ | T-cell engraftment; variable recovery of humoral immunity | X | ✔ | For patients younger than 3.5 months, T-cell engraftment; variable recovery of humoral immunity |
| T-B+NK+ | ✔ | T-cell engraftment; recovery of humoral immunity | X | ✔ | For patients younger than 3.5 months, T-cell engraftment; recovery of humoral immunity |
| ADA SCID | ✔ | T-cell engraftment; recovery of humoral immunity | X | X | |
| T-B-NK + (VDJ recombination defects) | X | Poor T-cell recovery; absent humoral recovery; may require repeat HSCT | X | X | |
| Other SCID forms | X | X | X |