Immunopathological features and IgH clonality of lymphomas in IL-10R–deficient patients
| Patient . | Lymphoma . | Biopsy . | Classification . | CD20 . | BCL2 . | CD10 . | BCL6 . | CD30 . | KI67 . | MUM-1 . | EBER . | c-REL . | IgH . | MYC . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | L1 | Liver | DLBCL | +++ | N/D | N/D | N/D | N/D | N/D | N/D | – | N/D | N/D | − |
| P2 | L1 | Liver | DLBCL | +++ | +/− | – | + | – | +++ | – | – | C++/N++ | Monoclonal | − |
| P3 | L1 | LN | DLBCL | +++ | – | + | + | – | +++ | – | – | C++/N+ | Monoclonal | − |
| P4 | L1 | Spleen | DLBCL | +++ | + | – | + | + | +++ | +/− | – | C++/N++ | Monoclonal | − |
| L2 | LN | DLBCL | +++ | – | + | + | + | +++ | + | – | C++/N+/− | Monoclonal | − | |
| L3 | LN | DLBCL | +++ | – | – | + | + | +++ | +/− | – | C++/N+ | Monoclonal | − | |
| L4 | LN | DLBCL | +++ | +/− | + | + | + | +++ | + | – | C++/N+ | N/D | − | |
| P5 | L1 | LN | DLBCL | +++ | + | + | + | – | +++ | +/− | – | C++/N+ | Monoclonal | N/D |
| Patient . | Lymphoma . | Biopsy . | Classification . | CD20 . | BCL2 . | CD10 . | BCL6 . | CD30 . | KI67 . | MUM-1 . | EBER . | c-REL . | IgH . | MYC . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | L1 | Liver | DLBCL | +++ | N/D | N/D | N/D | N/D | N/D | N/D | – | N/D | N/D | − |
| P2 | L1 | Liver | DLBCL | +++ | +/− | – | + | – | +++ | – | – | C++/N++ | Monoclonal | − |
| P3 | L1 | LN | DLBCL | +++ | – | + | + | – | +++ | – | – | C++/N+ | Monoclonal | − |
| P4 | L1 | Spleen | DLBCL | +++ | + | – | + | + | +++ | +/− | – | C++/N++ | Monoclonal | − |
| L2 | LN | DLBCL | +++ | – | + | + | + | +++ | + | – | C++/N+/− | Monoclonal | − | |
| L3 | LN | DLBCL | +++ | – | – | + | + | +++ | +/− | – | C++/N+ | Monoclonal | − | |
| L4 | LN | DLBCL | +++ | +/− | + | + | + | +++ | + | – | C++/N+ | N/D | − | |
| P5 | L1 | LN | DLBCL | +++ | + | + | + | – | +++ | +/− | – | C++/N+ | Monoclonal | N/D |
Lymphomas were classified according to the World Health Organization.
–, negative staining; +/–, heterogeneous staining; +++, strongly positive staining; C, cytoplasm; LN, lymph node; MYC, rearrangement of MYC locus detected by FISH; N, nuclear; N/D, not done.