Table 1 Summary of individual Treg... | American Society of Hematology

Table 1

Summary of individual Treg product characteristics before and after expansion

UPN*	Before expansion			After expansion
	Pre-CD25 selection TNC (×10⁸)	Post-CD25 selection		TNC (×10⁶)	% CD4⁺CD25⁺	Absolute CD4⁺CD25⁺ (×10⁶)	Fold expansion	Suppression at 1:4 ratio
	Pre-CD25 selection TNC (×10⁸)	TNC (×10⁶)	% CD4⁺CD25⁺	TNC (×10⁶)	% CD4⁺CD25⁺	Absolute CD4⁺CD25⁺ (×10⁶)	Fold expansion	Suppression at 1:4 ratio
4689	27	6.51	44	7610	71	5403	1169	80
4741	13	7.26	49	5452	74	4034	751	79
4762	8	2.50	71	148	95	141	59	81
4778	16	6.60	60	1280	73	934	194	78
4837	34	19.20	63	11309	93	10517	589	86
4855	14	5.20	49	1030	95	979	198	87
4872	22	2.39	83	2261	97	2193	946	NA
4908	22	7.31	80	2880	95	2796	394	81
4915	19	8.40	82	1058	62	656	126	95
4930	21	4.44	87	937	91	853	211	39
4936	14	0.74	54	286	76	217	385	86
4963	16	7.23	58	2458	81	1991	340	89
4975	15	4.68	73	1039	87	904	222	87
5013	16	1.70	11	129	69	89	76	94
4654	17	9.66	69	753	96	723	78	89
5039	16	9.15	62	119	80	95	13	86
5002	18	5.40	59	151	86	130	28	87
5087	16	17.50	66	3290	95	3126	188	75
5083	16	9.90	61	1020	84	857	103	86
5117	16	3.30	67	1580	78	1232	476	74
5121	23	1.13	65	12500	87	10875	1106	85
5125	22	9.02	70	16200	78	12636	1796	49
5151	15	7.20	76	1230	88	1082	171	60
Median (range)	16 (8-34)	6.6 (0.74-19.2)	65 (11-87)	1230 (119-16 200)	86 (62-97)	1058 (74-12636)	211 (13-1796)	85.5 (39-95)

UPN*	Before expansion			After expansion
	Pre-CD25 selection TNC (×10⁸)	Post-CD25 selection		TNC (×10⁶)	% CD4⁺CD25⁺	Absolute CD4⁺CD25⁺ (×10⁶)	Fold expansion	Suppression at 1:4 ratio
	Pre-CD25 selection TNC (×10⁸)	TNC (×10⁶)	% CD4⁺CD25⁺	TNC (×10⁶)	% CD4⁺CD25⁺	Absolute CD4⁺CD25⁺ (×10⁶)	Fold expansion	Suppression at 1:4 ratio
4689	27	6.51	44	7610	71	5403	1169	80
4741	13	7.26	49	5452	74	4034	751	79
4762	8	2.50	71	148	95	141	59	81
4778	16	6.60	60	1280	73	934	194	78
4837	34	19.20	63	11309	93	10517	589	86
4855	14	5.20	49	1030	95	979	198	87
4872	22	2.39	83	2261	97	2193	946	NA
4908	22	7.31	80	2880	95	2796	394	81
4915	19	8.40	82	1058	62	656	126	95
4930	21	4.44	87	937	91	853	211	39
4936	14	0.74	54	286	76	217	385	86
4963	16	7.23	58	2458	81	1991	340	89
4975	15	4.68	73	1039	87	904	222	87
5013	16	1.70	11	129	69	89	76	94
4654	17	9.66	69	753	96	723	78	89
5039	16	9.15	62	119	80	95	13	86
5002	18	5.40	59	151	86	130	28	87
5087	16	17.50	66	3290	95	3126	188	75
5083	16	9.90	61	1020	84	857	103	86
5117	16	3.30	67	1580	78	1232	476	74
5121	23	1.13	65	12500	87	10875	1106	85
5125	22	9.02	70	16200	78	12636	1796	49
5151	15	7.20	76	1230	88	1082	171	60
Median (range)	16 (8-34)	6.6 (0.74-19.2)	65 (11-87)	1230 (119-16 200)	86 (62-97)	1058 (74-12636)	211 (13-1796)	85.5 (39-95)

reg indicates regulatory T cell; TNC, total nucleated cell; and UPN, unique patient number.

The UPN column is listed by the order of patient accrual and treatment in the protocol.