Multivariable Cox PH analyses of predictors of 1- to 180-d VTE recurrence among Olmsted County, MN residents with a first-lifetime VTE diagnosed in 1984-1997, by APTT therapeutic “threshold”
| Variable . | HR (95%CI) [P] . | |
|---|---|---|
| APTT threshold ≥ 40 s* . | APTT threshold ≥ 58 s† . | |
| BMI, kg/m2 | [.08] | [.14] |
| < 20 | 0.17 (0.02, 1.27) | 0.19 (0.02, 1.38) |
| 20 < 25 | Referent | Referent |
| 25 < 30 | 1.13 (0.65, 1.96) | 1.04 (0.60, 1.81) |
| ≥ 30 | 0.83 (0.44, 1.56) | 0.82 (0.44, 1.54) |
| Active cancer | 2.93 (1.82, 4.74) [< .001] | 2.82 (1.74, 4.55) [< .001] |
| Neurologic disease with leg paresis | 1.65 (0.69, 3.97) [.26] | 1.67 (0.69, 4.08) [.26] |
| Neurosurgery | 2.23 (0.73, 6.84) [.16] | 2.05 (0.65, 6.42) [.22] |
| APTT ≥ indicated seconds within 24 ± 4 h of starting heparin | 0.87 (0.40, 1.91) [.73] | 0.57 (0.34, 0.97) [.04] |
| Proportion of time on heparin with APTT ≥ indicated seconds per 10% increase | 0.90 (0.83, 0.97) [< .01] | 0.96 (0.89, 1.04) [.33] |
| Proportion of time on warfarin with 1.5 ≤ INR < 2.0 per 10% increase | 0.98 (0.84, 1.14) [.76] | 0.97 (0.83, 1.13) [.71] |
| Proportion of time on warfarin with INR ≥ 2.0 per 10% increase | 0.83 (0.77, 0.90) [< .001] | 0.83 (0.77, 0.90) [< .001] |
| Inferior vena cava filter placement | 1.54 (0.76, 3.11) [.23] | 1.66 (0.82, 3.37) [.16] |
| Variable . | HR (95%CI) [P] . | |
|---|---|---|
| APTT threshold ≥ 40 s* . | APTT threshold ≥ 58 s† . | |
| BMI, kg/m2 | [.08] | [.14] |
| < 20 | 0.17 (0.02, 1.27) | 0.19 (0.02, 1.38) |
| 20 < 25 | Referent | Referent |
| 25 < 30 | 1.13 (0.65, 1.96) | 1.04 (0.60, 1.81) |
| ≥ 30 | 0.83 (0.44, 1.56) | 0.82 (0.44, 1.54) |
| Active cancer | 2.93 (1.82, 4.74) [< .001] | 2.82 (1.74, 4.55) [< .001] |
| Neurologic disease with leg paresis | 1.65 (0.69, 3.97) [.26] | 1.67 (0.69, 4.08) [.26] |
| Neurosurgery | 2.23 (0.73, 6.84) [.16] | 2.05 (0.65, 6.42) [.22] |
| APTT ≥ indicated seconds within 24 ± 4 h of starting heparin | 0.87 (0.40, 1.91) [.73] | 0.57 (0.34, 0.97) [.04] |
| Proportion of time on heparin with APTT ≥ indicated seconds per 10% increase | 0.90 (0.83, 0.97) [< .01] | 0.96 (0.89, 1.04) [.33] |
| Proportion of time on warfarin with 1.5 ≤ INR < 2.0 per 10% increase | 0.98 (0.84, 1.14) [.76] | 0.97 (0.83, 1.13) [.71] |
| Proportion of time on warfarin with INR ≥ 2.0 per 10% increase | 0.83 (0.77, 0.90) [< .001] | 0.83 (0.77, 0.90) [< .001] |
| Inferior vena cava filter placement | 1.54 (0.76, 3.11) [.23] | 1.66 (0.82, 3.37) [.16] |