Contribution of height, VKORC1, CYP2C9*2 and *3 genotypes, and indication for warfarin to regression equation for modeling warfarin daily dose requirements in children
| x variable . | P . | Contribution to model, % . |
|---|---|---|
| Height | < .001 | 29.8 |
| VKORC1 | < .001 | 26.6 |
| CYP2C9*3 | < .001 | 12.8 |
| CYP2C9*2 | < .001 | |
| Indication | < .001 | 3.2 |
| Height, VKORC1, CYP2C9*2/*3, indication | < .001 | 72.4 |
| x variable . | P . | Contribution to model, % . |
|---|---|---|
| Height | < .001 | 29.8 |
| VKORC1 | < .001 | 26.6 |
| CYP2C9*3 | < .001 | 12.8 |
| CYP2C9*2 | < .001 | |
| Indication | < .001 | 3.2 |
| Height, VKORC1, CYP2C9*2/*3, indication | < .001 | 72.4 |
Regression equation: √dose = −0.009 + 0.011 (height) + 0.357 (VKORC1) − 0.478 (CYP2C9*3) − 0.277 (CYP2C9*2) + 0.186 (indication). Height: input height in centimeters; VKORC1 genotype: input 0 for AA, 1 for AG, and 2 for GG; CYP2C9*3 genotype: input 0, 1, or 2 for the number of *3 alleles; CYP2C9*2 genotype: input 0, 1, or 2 for the number of *2 alleles; indication: input 0 for Fontan procedure, 1 for other indication. The 95% confidence intervals for the coefficients are: intercept (−0.313, 0.294), height (0.009, 0.013), VKORC1 (0.284, 0.425), CYP2C9*3 (−0.335, −0.621), CYP2C9*2 (−0.148, −0.407), and indication (0.085, 0.29).