Physical, hematological, and serum parameters of 4-week-old Hfe−/−Tmprss6+/+, Hfe−/−Tmprss6+/−, and Hfe−/−Tmprss6−/− mice
| Genotype . | Body wt, g . | Whole blood . | Serum . | |||||
|---|---|---|---|---|---|---|---|---|
| RBC, × 1012/L . | Hgb, g/L . | Hct . | MCV, × 10−15/L . | MCH, pg . | RDW, % . | Iron, μM . | ||
| Hfe−/−Tmprss6+/+ | 15 ± 2 | 7.6 ± 0.5 | 136 ± 11 | 0.419 ± 0.030 | 55.5 ± 0.7 | 17.9 ± 0.5 | 20.0 ± 3.1 | 38.4 ± 3.7 |
| Hfe−/−Tmprss6+/− | 16 ± 2 | 8.0 ± 0.3 | 141 ± 8 | 0.436 ± 0.024 | 54.6 ± 1.2 | 17.6 ± 0.5 | 18.7 ± 2.2 | 37.3 ± 5.8 |
| Hfe−/−Tmprss6−/− | 13 ± 1*† | 7.4 ± 0.5‡ | 89 ± 4§† | 0.291 ± 0.019§† | 39.4 ± 0.7§† | 12.2 ± 0.2§† | 37.0 ± 3.2§† | 5.3 ± 3.5§† |
| Genotype . | Body wt, g . | Whole blood . | Serum . | |||||
|---|---|---|---|---|---|---|---|---|
| RBC, × 1012/L . | Hgb, g/L . | Hct . | MCV, × 10−15/L . | MCH, pg . | RDW, % . | Iron, μM . | ||
| Hfe−/−Tmprss6+/+ | 15 ± 2 | 7.6 ± 0.5 | 136 ± 11 | 0.419 ± 0.030 | 55.5 ± 0.7 | 17.9 ± 0.5 | 20.0 ± 3.1 | 38.4 ± 3.7 |
| Hfe−/−Tmprss6+/− | 16 ± 2 | 8.0 ± 0.3 | 141 ± 8 | 0.436 ± 0.024 | 54.6 ± 1.2 | 17.6 ± 0.5 | 18.7 ± 2.2 | 37.3 ± 5.8 |
| Hfe−/−Tmprss6−/− | 13 ± 1*† | 7.4 ± 0.5‡ | 89 ± 4§† | 0.291 ± 0.019§† | 39.4 ± 0.7§† | 12.2 ± 0.2§† | 37.0 ± 3.2§† | 5.3 ± 3.5§† |
Complete blood counts and SI were measured in 4-week-old female mice. The numbers of mice per genotype analyzed were: 8 Hfe−/−Tmprss6+/+, 8 Hfe−/−Tmprss6+/−, and 6 Hfe−/−Tmprss6−/− mice. Data are presented as means ± SD.
Hct indicates hematocrit; and RDW, red cell distribution width.
P < .05 compared with Hfe−/−Tmprss6+/+ mice.
P < .005 compared with Hfe−/−Tmprss6+/− mice.
P < .05 compared with Hfe−/−Tmprss6+/− mice.
P < .005 compared with Hfe−/−Tmprss6+/+ mice.