Potential mechanisms of miRNA deregulation in NKTL
| Dysregulated miRNA . | Dysregulated in NKTL . | Genomic loci . | Affected by EBV infection . | Host gene . | Correlation with host gene expression . | Abnormality in genomic loci . | aCGH band . |
|---|---|---|---|---|---|---|---|
| hsa-miR-342–5p | − | Chromosome 14 | EVL | ||||
| hsa-miR-26b | − | Chromosome 2 | CTDSP1 | ||||
| hsa-miR-363 | − | Chromosome X | |||||
| hsa-miR-150 | − | Chromosome 19 | |||||
| hsa-miR-28–5p | − | Chromosome 3 | LPP | ||||
| hsa-miR-152 | − | Chromosome 17 | + | COPZ2 | Yes | ||
| hsa-miR-361–3p | − | Chromosome X | CHM | ||||
| hsa-miR-22* | − | Chromosome 17 | C17orf91 | ||||
| hsa-miR-340 | − | Chromosome 5 | RNF130 | ||||
| hsa-miR-598 | − | Chromosome 8 | XKR6 | Yes | |||
| hsa-miR-181a-2* | − | Chromosome 9 | NR6A1 | ||||
| hsa-miR-132 | − | Chromosome 17 | |||||
| hsa-miR-194 | − | Chromosome 1 | IARS2 | ||||
| hsa-miR-768–3p | − | Chromosome 16 | AP1G1 | ||||
| hsa-miR-873 | − | Chromosome 9 | |||||
| hsa-miR-338–3p | − | Chromosome 17 | AATK | ||||
| hsa-miR-215 | − | Chromosome 1 | IARS2 | ||||
| hsa-miR-186 | − | Chromosome 1 | ZRANB2 | − | 1p21.3-p31.2 | ||
| hsa-miR-140–3p | − | Chromosome 16 | WWP2 | ||||
| hsa-miR-140–5p | − | Chromosome 16 | WWP2 | ||||
| hsa-miR-374b | − | Chromosome X | NCRNA00182 | ||||
| hsa-miR-26a | − | Chromosome 12 | CTDSP2 | ||||
| hsa-let-7g | − | Chromosome 3 | − | WDR82 | |||
| hsa-miR-342–3p | − | Chromosome 14 | EVL | ||||
| hsa-miR-101 | − | Chromosome 1 | − | 1p21.3-p31.2 | |||
| hsa-miR-192 | − | Chromosome 11 | |||||
| hsa-miR-374a | − | Chromosome X | NCRNA00182 | ||||
| hsa-miR-876–5p | − | Chromosome 9 | |||||
| hsa-miR-22 | − | Chromosome 17 | C17orf91 | ||||
| hsa-miR-10a | − | Chromosome 17 | |||||
| hsa-miR-590–5p | − | Chromosome 7 | EIF4H | ||||
| hsa-miR-30b | − | Chromosome 8 | |||||
| hsa-miR-181c | − | Chromosome 19 | |||||
| hsa-miR-142–5p | − | Chromosome 17 | |||||
| hsa-let-7a | − | Chromosome 11 | − | LOC399959 | |||
| hsa-miR-155 | + | Chromosome 21 | + | MIR155HG | |||
| hsa-let-7c | − | Chromosome 21 | − | C21orf34 | |||
| hsa-miR-378 | + | Chromosome 5 | PPARGC1B | Yes | |||
| hsa-miR-181a | − | Chromosome 1 | |||||
| hsa-miR-142–3p | − | Chromosome 17 | |||||
| hsa-miR-15a | − | Chromosome 13 | DLEU2 |
| Dysregulated miRNA . | Dysregulated in NKTL . | Genomic loci . | Affected by EBV infection . | Host gene . | Correlation with host gene expression . | Abnormality in genomic loci . | aCGH band . |
|---|---|---|---|---|---|---|---|
| hsa-miR-342–5p | − | Chromosome 14 | EVL | ||||
| hsa-miR-26b | − | Chromosome 2 | CTDSP1 | ||||
| hsa-miR-363 | − | Chromosome X | |||||
| hsa-miR-150 | − | Chromosome 19 | |||||
| hsa-miR-28–5p | − | Chromosome 3 | LPP | ||||
| hsa-miR-152 | − | Chromosome 17 | + | COPZ2 | Yes | ||
| hsa-miR-361–3p | − | Chromosome X | CHM | ||||
| hsa-miR-22* | − | Chromosome 17 | C17orf91 | ||||
| hsa-miR-340 | − | Chromosome 5 | RNF130 | ||||
| hsa-miR-598 | − | Chromosome 8 | XKR6 | Yes | |||
| hsa-miR-181a-2* | − | Chromosome 9 | NR6A1 | ||||
| hsa-miR-132 | − | Chromosome 17 | |||||
| hsa-miR-194 | − | Chromosome 1 | IARS2 | ||||
| hsa-miR-768–3p | − | Chromosome 16 | AP1G1 | ||||
| hsa-miR-873 | − | Chromosome 9 | |||||
| hsa-miR-338–3p | − | Chromosome 17 | AATK | ||||
| hsa-miR-215 | − | Chromosome 1 | IARS2 | ||||
| hsa-miR-186 | − | Chromosome 1 | ZRANB2 | − | 1p21.3-p31.2 | ||
| hsa-miR-140–3p | − | Chromosome 16 | WWP2 | ||||
| hsa-miR-140–5p | − | Chromosome 16 | WWP2 | ||||
| hsa-miR-374b | − | Chromosome X | NCRNA00182 | ||||
| hsa-miR-26a | − | Chromosome 12 | CTDSP2 | ||||
| hsa-let-7g | − | Chromosome 3 | − | WDR82 | |||
| hsa-miR-342–3p | − | Chromosome 14 | EVL | ||||
| hsa-miR-101 | − | Chromosome 1 | − | 1p21.3-p31.2 | |||
| hsa-miR-192 | − | Chromosome 11 | |||||
| hsa-miR-374a | − | Chromosome X | NCRNA00182 | ||||
| hsa-miR-876–5p | − | Chromosome 9 | |||||
| hsa-miR-22 | − | Chromosome 17 | C17orf91 | ||||
| hsa-miR-10a | − | Chromosome 17 | |||||
| hsa-miR-590–5p | − | Chromosome 7 | EIF4H | ||||
| hsa-miR-30b | − | Chromosome 8 | |||||
| hsa-miR-181c | − | Chromosome 19 | |||||
| hsa-miR-142–5p | − | Chromosome 17 | |||||
| hsa-let-7a | − | Chromosome 11 | − | LOC399959 | |||
| hsa-miR-155 | + | Chromosome 21 | + | MIR155HG | |||
| hsa-let-7c | − | Chromosome 21 | − | C21orf34 | |||
| hsa-miR-378 | + | Chromosome 5 | PPARGC1B | Yes | |||
| hsa-miR-181a | − | Chromosome 1 | |||||
| hsa-miR-142–3p | − | Chromosome 17 | |||||
| hsa-miR-15a | − | Chromosome 13 | DLEU2 |
– indicates down-regulated; +, upregulated; and empty fields, no abnormalities detected.