Table 1

Deregulated miRNA in NKTL and NK cell lines compared with normal NK cells

miRNACell lines versus normal
NKTL versus normal
Chromosome locationGenomic positionTarget genes
q-valueFold changeq-valueFold change
hsa-miR-342–5p 0.00047 0.17804 0.00000 0.17231 14 099645783-099645765 POFUT1 
hsa-miR-26b 0.00049 0.05876 0.00000 0.02942 2 218975644-218975625 BCL2, IGF1, SETD7, FOXP2, CAPRIN1, PSD3, HOXA5, KPNA2, E2F7, ENPEP, EZH2, HMGA1, NAMPT, PIM1, SC4MOL, ACVR1C, AGPAT5, ASCC3, CKS2, CTTNBP2NL, DCDC2, IARS, KIF18A, LARP1, MTM1, NFE2L3, NUP50, SLC7A11 
hsa-miR-363 0.00049 0.05325 0.00000 0.06310 X 133131078-133131095 BCL2, IGF1, SETD7, FOXP2, PSD3, ATP2A2, BCAT2, DOCK9, SMAD6, ADCY3, ASB7, CHCHD10, FMN2, NFIB, RAB23, RGL1, SLC7A11, YIPF4 
hsa-miR-150 0.00049 0.00483 0.00000 0.01099 19 054695901-054695916 MYB, ELK1, CTH, ENSA 
hsa-miR-28–5p 0.00049 0.17303 0.00000 0.14000 3 189889297-189889278 IGF1, SETD7, CAPRIN1, HTRA2, MAD2L1, TLN2 
hsa-miR-152 0.00049 0.28067 0.00000 0.27612 17 043469539-043469553 E2F7, ANK2, ATP2A2, B4GALT2, BBC3, CEP55, DPP3, EMP1, HMGB3, IGF1, KLC2 
hsa-miR-361–3p 0.00049 0.23188 0.00000 0.19701 X 085045302-085045320 CD3EAP, OSR2 
hsa-miR-22* 0.00049 0.32882 0.00000 0.34642 17 001563996-001564012 No predicted targets 
hsa-miR-340 0.00049 0.26426 0.00000 0.29925 5 179374967-179374984 AGPAT5, AHR, CDON, CIT, DEPDC1B, E2F7, FHL2, GK, HECW2, IGF1, ING3, MYO1C, NUPL1, PHLDA1, SLC7A11, TIAM1 
hsa-miR-598 0.00049 0.49291 0.00000 0.48708 8 010930141-010930158 No predicted targets 
hsa-miR-181a-2* 0.00049 0.23242 0.00000 0.22641 9 126494639-126494623 No predicted targets 
hsa-miR-132 0.00050 0.45398 0.00000 0.42973 17 001899973-001899987 HBEGF, BRI3, HN1, TLN2, VDAC2, ADCY3, AHCY, AZIN1, CAPRIN1, FKBP2, NFIB, PPM1G, SCN2A, TRIB1, TTK 
hsa-miR-194 0.00050 0.32209 0.00024 0.32691 1 218358171-218358185 HBEGF, TLN2, CTAGE5, LPHN2, PRR7, VDAC2 
hsa-miR-768–3p 0.00050 0.13168 0.00000 0.08066 16 070349814-070349832 AHR, CENPE, HOXA4 
hsa-miR-873 0.00050 0.22803 0.00000 0.22284 9 028878923-028878939 FOXK2, MPDU1, TLN2 
hsa-miR-338–3p 0.00052 0.13277 0.00001 0.15864 17 076714282-076714301 FKBP1A, ARPC1B 
hsa-miR-215 0.00053 0.44650 0.00119 0.45644 1 218357881-218357900 DYRK3, LPAR4, TRIP13 
hsa-miR-186 0.00054 0.26956 0.00000 0.14583 1 071305952-071305971 CDC42, BTF3, PPM1G, SMAD6, ACSL4, BCAT1, BMP2K, EIF2S2, ENPEP, PRDM1, PSD3, PSMD11, PSPH, RGS22, VEGFA, ZCCHC5 
hsa-miR-140–3p 0.00054 0.27234 0.00000 0.16194 16 068524566-068524552 FOXK2, UBE2C 
hsa-miR-140–5p 0.00054 0.30678 0.00000 0.13482 16 068524528-068524508 ARHGAP19, CASP3, ST5, TTK 
hsa-miR-374b 0.00055 0.32813 0.00000 0.13347 X 073355147-073355164 TFDP1, CCNE2, EIF2S2, EIF4G1, ENSA, GNB2, HOXA11, HSPA4, HTRA2, LARP1, NFIB, SMAD6 
hsa-miR-26a 0.00056 0.14699 0.00048 0.23283 12 056504708-056504721 BCL2, IGF1, SETD7, PSD3, EZH2, HOXA5, KPNA2, E2F7, ENPEP, HMGA1, NAMPT, PIM1, SC4MOL, ASCC3, CKS2, CTTNBP2NL, DCDC2, IARS, KIF18A, LARP1, MTM1, NFE2L3, NUP50, SLC7A11 
hsa-let-7g 0.00057 0.21467 0.00001 0.10030 3 052277392-052277411 ACVR1C, AP1S1, CASP3, CDC25A, COL15A1, CYP19A1, DPP3, EZH2, FAM118A, POLR3D, SCD, TARBP2, TTLL4, ATP2A2, BCAP29, BCAT1, CCNF, CD86, DUSP4, HMGA1, RGS16, SOCS1, THRSP, ZCCHC5 
hsa-miR-342–3p 0.00057 0.14972 0.00000 0.07856 14 099645827-099645812 ENSA, SLC35F2, TIAM1 
hsa-miR-101 0.00057 0.33272 0.00000 0.09962 1 065296713-065296731 STMN1, BCL2, IGF1, PSD3, EZH2, EMP1, ING3, PANK3, PHLDA1, TRIB1, ACCN2, ASCC3, DDIT4, HNRNPAB, LMNB1, POMP, SCN2A, SELI 
hsa-miR-192 0.00060 0.33056 0.00044 0.32841 11 064415251-064415268 DYRK3, LPAR4, TRIP13 
hsa-miR-374a 0.00065 0.29720 0.00000 0.09324 X 073423885-073423905 EIF2S2, ENSA, GK, GNB2, HOXA11, HSPA4, LARP1, NFIB, SMAD6, TFDP1 
hsa-miR-876–5p 0.00070 0.43160 0.00004 0.39927 9 028853673-028853691 EME1, FOXM1, DNAJC12, NTRK2, PHLDA1, TFAP2A, ZCCHC5 
hsa-miR-22 0.00076 0.19107 0.00000 0.19752 17 001563958-001563975 BATF3, DDIT4, HOXA4, IPO7, MTHFD2, RFXANK, APBB2, NET1, PPM1G, TIAM1 
hsa-miR-10a 0.00111 0.42780 0.00008 0.36971 17 044012265-044012284 BCL6, SOBP, STK24, TIAM1, ZNF367 
hsa-miR-590–5p 0.00168 0.45785 0.00000 0.17107 7 073243500-073243479 ING3, NFIB, RBPJ, TIAM1, ZNF367 
hsa-miR-30b 0.00258 0.26088 0.00000 0.09993 8 135881995-135882010 ADAM22, DDIT4, NFIB, PPARGC1B, SCN2A, SLC41A2, ASCC3, CCNE2, CELSR3, FGD6, PRDM1, RHEBL1, SCN8A, SMARCD2, SOCS1, AVEN, AZIN1, BCL2, DEPDC4, FRMD6, HOXA11, IL2RA, IRF4, ITSN1, MTA1, PRICKLE1, RGL1, SETD7, STXBP1, SUPT3H, TFDP1 
hsa-miR-181c 0.00324 0.40588 0.00000 0.24845 19 013846560-013846542 FKBP1A, NR6A1, CTTNBP2NL, DDIT4, E2F7, HOXA11, NR4A3, APOO, ATP2A2, CDON, FAM3C, IPPK, ITSN1, MAP1A, MINA, NLN, PDIA6, PHLDA1, PRDX3, SCD, SLC25A37 
hsa-miR-142–5p 0.00404 0.34288 0.00000 0.01692 17 053763643-053763660 SRI, AHR, HN1, PPM1G, RBBP8, RNH1, SLC41A2 
hsa-let-7a 0.00602 0.45269 0.00420 0.37315 11 121522486-121522504 ACVR1C, AP1S1, CASP3, CDC25A, CYP19A1, DPP3, EZH2, SCD, TARBP2, ATP2A2, BCAP29, BCAT1, BRF2, CCNF, COL15A1, DUSP4, FAM118A, HOXB4, POLR3D, RGS16, SOCS1, THRSP, TRIB1, TTLL4, ZCCHC5 
hsa-miR-155 0.00690 11.45284 0.00119 2.16728 21 025868188-025868172 BNC2, SGK3, TLE4, TSHZ3, EIF2C4, FGF7, GPM6B, KLRC3, LHX9, MYLK, PCDH9, PDLIM5, RAB34, RREB1, SOX11, ZNF618 
hsa-let-7c 0.01070 0.27938 0.00160 0.41876 21 016834050-016834032 ACVR1C, CASP3, CDC25A, CYP19A1, DPP3, EZH2, SCD, TARBP2, TTLL4, AP1S1, ATP2A2, BCAT1, BRF2, CCNF, COL15A1, DUSP4, FAM118A, HOXB4, POLR3D, RGS16, SOCS1, THRSP, TRIB1 
hsa-miR-378 0.01145 2.53182 0.00059 4.08760 5 149092643-149092631 GPM6B, IGF1R, WDR37 
hsa-miR-181a 0.01665 0.38679 0.00000 0.16954 1 197094860-197094873 FKBP1A, NR6A1, CTTNBP2NL, DDIT4, E2F7, HOXA11, NR4A3, APOO, ATP2A2, CDON, FAM3C, IPPK, ITSN1, MAP1A, MINA, NLN, PDIA6, PHLDA1, PLAU, PRDX3, SCD, SLC25A37 
hsa-miR-142–3p 0.01796 0.45692 0.00000 0.01686 17 053763605-053763626 TFG, FKBP1A, GNB2, ATP2A2 
hsa-miR-15a 0.04502 0.49695 0.00000 0.13992 13 049521304-049521323 CCNE1, CDCA4, CHEK1, MYB, WEE1, CDC25A, KIF23, LPHN2, PDIA6, PPAP2A, SMARCD2, STXBP1, TARBP2, ACSL4, ANKRD13B, BCL2, BTF3, CDC42, E2F7, FKBP1A, FSD1, IARS, LIPE, OTX1, PANK1, PHF19, PIM1, PPIF, PPIL1, PTPN3, SELI, SMYD5, ZCCHC5 
miRNACell lines versus normal
NKTL versus normal
Chromosome locationGenomic positionTarget genes
q-valueFold changeq-valueFold change
hsa-miR-342–5p 0.00047 0.17804 0.00000 0.17231 14 099645783-099645765 POFUT1 
hsa-miR-26b 0.00049 0.05876 0.00000 0.02942 2 218975644-218975625 BCL2, IGF1, SETD7, FOXP2, CAPRIN1, PSD3, HOXA5, KPNA2, E2F7, ENPEP, EZH2, HMGA1, NAMPT, PIM1, SC4MOL, ACVR1C, AGPAT5, ASCC3, CKS2, CTTNBP2NL, DCDC2, IARS, KIF18A, LARP1, MTM1, NFE2L3, NUP50, SLC7A11 
hsa-miR-363 0.00049 0.05325 0.00000 0.06310 X 133131078-133131095 BCL2, IGF1, SETD7, FOXP2, PSD3, ATP2A2, BCAT2, DOCK9, SMAD6, ADCY3, ASB7, CHCHD10, FMN2, NFIB, RAB23, RGL1, SLC7A11, YIPF4 
hsa-miR-150 0.00049 0.00483 0.00000 0.01099 19 054695901-054695916 MYB, ELK1, CTH, ENSA 
hsa-miR-28–5p 0.00049 0.17303 0.00000 0.14000 3 189889297-189889278 IGF1, SETD7, CAPRIN1, HTRA2, MAD2L1, TLN2 
hsa-miR-152 0.00049 0.28067 0.00000 0.27612 17 043469539-043469553 E2F7, ANK2, ATP2A2, B4GALT2, BBC3, CEP55, DPP3, EMP1, HMGB3, IGF1, KLC2 
hsa-miR-361–3p 0.00049 0.23188 0.00000 0.19701 X 085045302-085045320 CD3EAP, OSR2 
hsa-miR-22* 0.00049 0.32882 0.00000 0.34642 17 001563996-001564012 No predicted targets 
hsa-miR-340 0.00049 0.26426 0.00000 0.29925 5 179374967-179374984 AGPAT5, AHR, CDON, CIT, DEPDC1B, E2F7, FHL2, GK, HECW2, IGF1, ING3, MYO1C, NUPL1, PHLDA1, SLC7A11, TIAM1 
hsa-miR-598 0.00049 0.49291 0.00000 0.48708 8 010930141-010930158 No predicted targets 
hsa-miR-181a-2* 0.00049 0.23242 0.00000 0.22641 9 126494639-126494623 No predicted targets 
hsa-miR-132 0.00050 0.45398 0.00000 0.42973 17 001899973-001899987 HBEGF, BRI3, HN1, TLN2, VDAC2, ADCY3, AHCY, AZIN1, CAPRIN1, FKBP2, NFIB, PPM1G, SCN2A, TRIB1, TTK 
hsa-miR-194 0.00050 0.32209 0.00024 0.32691 1 218358171-218358185 HBEGF, TLN2, CTAGE5, LPHN2, PRR7, VDAC2 
hsa-miR-768–3p 0.00050 0.13168 0.00000 0.08066 16 070349814-070349832 AHR, CENPE, HOXA4 
hsa-miR-873 0.00050 0.22803 0.00000 0.22284 9 028878923-028878939 FOXK2, MPDU1, TLN2 
hsa-miR-338–3p 0.00052 0.13277 0.00001 0.15864 17 076714282-076714301 FKBP1A, ARPC1B 
hsa-miR-215 0.00053 0.44650 0.00119 0.45644 1 218357881-218357900 DYRK3, LPAR4, TRIP13 
hsa-miR-186 0.00054 0.26956 0.00000 0.14583 1 071305952-071305971 CDC42, BTF3, PPM1G, SMAD6, ACSL4, BCAT1, BMP2K, EIF2S2, ENPEP, PRDM1, PSD3, PSMD11, PSPH, RGS22, VEGFA, ZCCHC5 
hsa-miR-140–3p 0.00054 0.27234 0.00000 0.16194 16 068524566-068524552 FOXK2, UBE2C 
hsa-miR-140–5p 0.00054 0.30678 0.00000 0.13482 16 068524528-068524508 ARHGAP19, CASP3, ST5, TTK 
hsa-miR-374b 0.00055 0.32813 0.00000 0.13347 X 073355147-073355164 TFDP1, CCNE2, EIF2S2, EIF4G1, ENSA, GNB2, HOXA11, HSPA4, HTRA2, LARP1, NFIB, SMAD6 
hsa-miR-26a 0.00056 0.14699 0.00048 0.23283 12 056504708-056504721 BCL2, IGF1, SETD7, PSD3, EZH2, HOXA5, KPNA2, E2F7, ENPEP, HMGA1, NAMPT, PIM1, SC4MOL, ASCC3, CKS2, CTTNBP2NL, DCDC2, IARS, KIF18A, LARP1, MTM1, NFE2L3, NUP50, SLC7A11 
hsa-let-7g 0.00057 0.21467 0.00001 0.10030 3 052277392-052277411 ACVR1C, AP1S1, CASP3, CDC25A, COL15A1, CYP19A1, DPP3, EZH2, FAM118A, POLR3D, SCD, TARBP2, TTLL4, ATP2A2, BCAP29, BCAT1, CCNF, CD86, DUSP4, HMGA1, RGS16, SOCS1, THRSP, ZCCHC5 
hsa-miR-342–3p 0.00057 0.14972 0.00000 0.07856 14 099645827-099645812 ENSA, SLC35F2, TIAM1 
hsa-miR-101 0.00057 0.33272 0.00000 0.09962 1 065296713-065296731 STMN1, BCL2, IGF1, PSD3, EZH2, EMP1, ING3, PANK3, PHLDA1, TRIB1, ACCN2, ASCC3, DDIT4, HNRNPAB, LMNB1, POMP, SCN2A, SELI 
hsa-miR-192 0.00060 0.33056 0.00044 0.32841 11 064415251-064415268 DYRK3, LPAR4, TRIP13 
hsa-miR-374a 0.00065 0.29720 0.00000 0.09324 X 073423885-073423905 EIF2S2, ENSA, GK, GNB2, HOXA11, HSPA4, LARP1, NFIB, SMAD6, TFDP1 
hsa-miR-876–5p 0.00070 0.43160 0.00004 0.39927 9 028853673-028853691 EME1, FOXM1, DNAJC12, NTRK2, PHLDA1, TFAP2A, ZCCHC5 
hsa-miR-22 0.00076 0.19107 0.00000 0.19752 17 001563958-001563975 BATF3, DDIT4, HOXA4, IPO7, MTHFD2, RFXANK, APBB2, NET1, PPM1G, TIAM1 
hsa-miR-10a 0.00111 0.42780 0.00008 0.36971 17 044012265-044012284 BCL6, SOBP, STK24, TIAM1, ZNF367 
hsa-miR-590–5p 0.00168 0.45785 0.00000 0.17107 7 073243500-073243479 ING3, NFIB, RBPJ, TIAM1, ZNF367 
hsa-miR-30b 0.00258 0.26088 0.00000 0.09993 8 135881995-135882010 ADAM22, DDIT4, NFIB, PPARGC1B, SCN2A, SLC41A2, ASCC3, CCNE2, CELSR3, FGD6, PRDM1, RHEBL1, SCN8A, SMARCD2, SOCS1, AVEN, AZIN1, BCL2, DEPDC4, FRMD6, HOXA11, IL2RA, IRF4, ITSN1, MTA1, PRICKLE1, RGL1, SETD7, STXBP1, SUPT3H, TFDP1 
hsa-miR-181c 0.00324 0.40588 0.00000 0.24845 19 013846560-013846542 FKBP1A, NR6A1, CTTNBP2NL, DDIT4, E2F7, HOXA11, NR4A3, APOO, ATP2A2, CDON, FAM3C, IPPK, ITSN1, MAP1A, MINA, NLN, PDIA6, PHLDA1, PRDX3, SCD, SLC25A37 
hsa-miR-142–5p 0.00404 0.34288 0.00000 0.01692 17 053763643-053763660 SRI, AHR, HN1, PPM1G, RBBP8, RNH1, SLC41A2 
hsa-let-7a 0.00602 0.45269 0.00420 0.37315 11 121522486-121522504 ACVR1C, AP1S1, CASP3, CDC25A, CYP19A1, DPP3, EZH2, SCD, TARBP2, ATP2A2, BCAP29, BCAT1, BRF2, CCNF, COL15A1, DUSP4, FAM118A, HOXB4, POLR3D, RGS16, SOCS1, THRSP, TRIB1, TTLL4, ZCCHC5 
hsa-miR-155 0.00690 11.45284 0.00119 2.16728 21 025868188-025868172 BNC2, SGK3, TLE4, TSHZ3, EIF2C4, FGF7, GPM6B, KLRC3, LHX9, MYLK, PCDH9, PDLIM5, RAB34, RREB1, SOX11, ZNF618 
hsa-let-7c 0.01070 0.27938 0.00160 0.41876 21 016834050-016834032 ACVR1C, CASP3, CDC25A, CYP19A1, DPP3, EZH2, SCD, TARBP2, TTLL4, AP1S1, ATP2A2, BCAT1, BRF2, CCNF, COL15A1, DUSP4, FAM118A, HOXB4, POLR3D, RGS16, SOCS1, THRSP, TRIB1 
hsa-miR-378 0.01145 2.53182 0.00059 4.08760 5 149092643-149092631 GPM6B, IGF1R, WDR37 
hsa-miR-181a 0.01665 0.38679 0.00000 0.16954 1 197094860-197094873 FKBP1A, NR6A1, CTTNBP2NL, DDIT4, E2F7, HOXA11, NR4A3, APOO, ATP2A2, CDON, FAM3C, IPPK, ITSN1, MAP1A, MINA, NLN, PDIA6, PHLDA1, PLAU, PRDX3, SCD, SLC25A37 
hsa-miR-142–3p 0.01796 0.45692 0.00000 0.01686 17 053763605-053763626 TFG, FKBP1A, GNB2, ATP2A2 
hsa-miR-15a 0.04502 0.49695 0.00000 0.13992 13 049521304-049521323 CCNE1, CDCA4, CHEK1, MYB, WEE1, CDC25A, KIF23, LPHN2, PDIA6, PPAP2A, SMARCD2, STXBP1, TARBP2, ACSL4, ANKRD13B, BCL2, BTF3, CDC42, E2F7, FKBP1A, FSD1, IARS, LIPE, OTX1, PANK1, PHF19, PIM1, PPIF, PPIL1, PTPN3, SELI, SMYD5, ZCCHC5 
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