Multiple variable modeling for hydroxyurea pharmacodynamics variables MTD HbF (%) and dose (mg/kg/d)
PD variable/order of selection . | Variable . | Direction of the association . |
---|---|---|
MTD HbF, % | ||
1 | Baseline HbF | Positive |
2 | Baseline ARC | Positive |
3 | Baseline total bilirubin | Negative |
4 | Baseline BMI | Positive |
5 | First-dose MRTinf | Negative |
MTD, mg/kg/d | ||
1 | Baseline creatinine | Negative |
2 | Baseline BMI | Negative |
3 | First-dose half-life | Negative |
4 | Baseline ARC | Positive |
5 | Fast PK phenotype | Positive |
PD variable/order of selection . | Variable . | Direction of the association . |
---|---|---|
MTD HbF, % | ||
1 | Baseline HbF | Positive |
2 | Baseline ARC | Positive |
3 | Baseline total bilirubin | Negative |
4 | Baseline BMI | Positive |
5 | First-dose MRTinf | Negative |
MTD, mg/kg/d | ||
1 | Baseline creatinine | Negative |
2 | Baseline BMI | Negative |
3 | First-dose half-life | Negative |
4 | Baseline ARC | Positive |
5 | Fast PK phenotype | Positive |