Table 2

Multiple variable modeling for hydroxyurea pharmacodynamics variables MTD HbF (%) and dose (mg/kg/d)

PD variable/order of selectionVariableDirection of the association
MTD HbF, %   
    1 Baseline HbF Positive 
    2 Baseline ARC Positive 
    3 Baseline total bilirubin Negative 
    4 Baseline BMI Positive 
    5 First-dose MRTinf Negative 
MTD, mg/kg/d   
    1 Baseline creatinine Negative 
    2 Baseline BMI Negative 
    3 First-dose half-life Negative 
    4 Baseline ARC Positive 
    5 Fast PK phenotype Positive 
PD variable/order of selectionVariableDirection of the association
MTD HbF, %   
    1 Baseline HbF Positive 
    2 Baseline ARC Positive 
    3 Baseline total bilirubin Negative 
    4 Baseline BMI Positive 
    5 First-dose MRTinf Negative 
MTD, mg/kg/d   
    1 Baseline creatinine Negative 
    2 Baseline BMI Negative 
    3 First-dose half-life Negative 
    4 Baseline ARC Positive 
    5 Fast PK phenotype Positive 
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