Multiple variable modeling for hydroxyurea pharmacodynamics variables MTD HbF (%) and dose (mg/kg/d)
| PD variable/order of selection . | Variable . | Direction of the association . |
|---|---|---|
| MTD HbF, % | ||
| 1 | Baseline HbF | Positive |
| 2 | Baseline ARC | Positive |
| 3 | Baseline total bilirubin | Negative |
| 4 | Baseline BMI | Positive |
| 5 | First-dose MRTinf | Negative |
| MTD, mg/kg/d | ||
| 1 | Baseline creatinine | Negative |
| 2 | Baseline BMI | Negative |
| 3 | First-dose half-life | Negative |
| 4 | Baseline ARC | Positive |
| 5 | Fast PK phenotype | Positive |
| PD variable/order of selection . | Variable . | Direction of the association . |
|---|---|---|
| MTD HbF, % | ||
| 1 | Baseline HbF | Positive |
| 2 | Baseline ARC | Positive |
| 3 | Baseline total bilirubin | Negative |
| 4 | Baseline BMI | Positive |
| 5 | First-dose MRTinf | Negative |
| MTD, mg/kg/d | ||
| 1 | Baseline creatinine | Negative |
| 2 | Baseline BMI | Negative |
| 3 | First-dose half-life | Negative |
| 4 | Baseline ARC | Positive |
| 5 | Fast PK phenotype | Positive |