Univariate summary statistics of first-dose hydroxyurea pharmacokinetics in 87 children with SCA
| Variable . | Mean . | SD . | Median . | Minimum . | Maximum . | CV (%) . |
|---|---|---|---|---|---|---|
| AUC [inf], μg·h/mL | 92.98 | 23.37 | 94.66 | 40.89 | 150.34 | 25.1 |
| CL/F, L/h | 6.92 | 3.17 | 6.46 | 1.57 | 21.59 | 45.8 |
| CL/F, L/h per kg | 0.24 | 0.09 | 0.21 | 0.12 | 0.80 | 37.5 |
| Cmax, μg/mL | 26.13 | 6.83 | 25.40 | 12.85 | 45.48 | 26.1 |
| Half-life, h | 1.70 | 0.53 | 1.67 | 0.65 | 3.05 | 31.2 |
| MRT, h | 3.17 | 0.78 | 2.99 | 2.08 | 6.08 | 24.6 |
| Tmax, h | 0.82 | 0.47 | 0.57 | 0.25 | 2.20 | 57.3 |
| V/F, L | 12.09 | 7.59 | 10.86 | 2.50 | 52.44 | 62.8 |
| Variable . | Mean . | SD . | Median . | Minimum . | Maximum . | CV (%) . |
|---|---|---|---|---|---|---|
| AUC [inf], μg·h/mL | 92.98 | 23.37 | 94.66 | 40.89 | 150.34 | 25.1 |
| CL/F, L/h | 6.92 | 3.17 | 6.46 | 1.57 | 21.59 | 45.8 |
| CL/F, L/h per kg | 0.24 | 0.09 | 0.21 | 0.12 | 0.80 | 37.5 |
| Cmax, μg/mL | 26.13 | 6.83 | 25.40 | 12.85 | 45.48 | 26.1 |
| Half-life, h | 1.70 | 0.53 | 1.67 | 0.65 | 3.05 | 31.2 |
| MRT, h | 3.17 | 0.78 | 2.99 | 2.08 | 6.08 | 24.6 |
| Tmax, h | 0.82 | 0.47 | 0.57 | 0.25 | 2.20 | 57.3 |
| V/F, L | 12.09 | 7.59 | 10.86 | 2.50 | 52.44 | 62.8 |
AUC is the total drug exposure (serum concentration over time) either until the final time point (tf) or extrapolated to infinity (inf), the difference between those two (extra), and D is dose.
CL/F indicates apparent oral clearance; Cmax, the maximum concentration; MRT, mean residence time (average time drug resides in the body); Tmax, time to Cmax; and V/F, apparent volume of distribution.