Table 4 Complications, GVHD, and outcome... | American Society of Hematology

Table 4

Complications, GVHD, and outcome*

Toxicity	No. of patients
Toxicity	Group A	Group B	All
Stomatitis
< 3rd degree	5	15	20
3rd or 4th degree	9	1	10
Gastrointestinal tract
< 3rd degree	9	11	20
3rd or 4th degree	5	5	10
Liver†
< 3rd degree	8	8	16
3rd or 4th degree	6	8	14
Kidney‡
< 3rd degree	12	12	24
3rd or 4th degree	2	4	6
Lung
< 3rd degree	12	11	23
3rd or 4th degree	2	5	7
Heart
< 3rd degree	12	15	27
3rd or 4th degree	2	1	3
Acute GVHD
< grade 2	8	11	19
Grade 2	4	5	9
Grade 3	1	0	1
Grade 4	1	0	1
Chronic GVHD (in evaluable patients)
None	7	11	18
Limited	2	2	4
Extended	2	3	5
Rejection and relapse
Graft rejection	1	1	2
Relapse of disease	6	1	7
Treatment-related mortality	2	2	4
Dead	5	2	7
Alive	9	14	23

Toxicity	No. of patients
Toxicity	Group A	Group B	All
Stomatitis
< 3rd degree	5	15	20
3rd or 4th degree	9	1	10
Gastrointestinal tract
< 3rd degree	9	11	20
3rd or 4th degree	5	5	10
Liver†
< 3rd degree	8	8	16
3rd or 4th degree	6	8	14
Kidney‡
< 3rd degree	12	12	24
3rd or 4th degree	2	4	6
Lung
< 3rd degree	12	11	23
3rd or 4th degree	2	5	7
Heart
< 3rd degree	12	15	27
3rd or 4th degree	2	1	3
Acute GVHD
< grade 2	8	11	19
Grade 2	4	5	9
Grade 3	1	0	1
Grade 4	1	0	1
Chronic GVHD (in evaluable patients)
None	7	11	18
Limited	2	2	4
Extended	2	3	5
Rejection and relapse
Graft rejection	1	1	2
Relapse of disease	6	1	7
Treatment-related mortality	2	2	4
Dead	5	2	7
Alive	9	14	23

Engraftment, toxicity, and GVHD were assessed by consensus criteria.^36,37

†

Two patients with preexisting liver disease developed fourth-degree toxicity of the liver; there were no other patients with fourth-degree toxicity of the liver.

‡

No fourth-degree toxicity of the kidney was observed.

View Large

This Feature Is Available To Subscribers Only