Comparison of characteristics based on EBV-infected cell type in 108 patients with EBV+ T/NK-LPD
| . | Total cells (n = 108) . | T cells (n = 64) . | NK cells (n = 44) . | P* . |
|---|---|---|---|---|
| Sex (male/female) | 50/58 | 27/37 | 23/21 | NS |
| Age at disease onset, y | 12.1 ± 10.6 | 12.7 ± 10.3 | 11.3 ± 11.0 | NS |
| Clinical category at diagnosis, n | ||||
| CAEBV | 80 | 47 | 33 | NS |
| HLH | 15 | 12 | 3 | .066 |
| Severe mosquito bite allergy | 9 | 1 | 8 | .003 |
| Hydroa vacciniforme | 4 | 4 | 0 | NS |
| Past history of infectious mononucleosis, n (%) | 37 (34) | 24 (22) | 13 (12) | NS |
| Primary infection at diagnosis, n (%) | 19 (18) | 16 (15) | 3 (3) | .012 |
| EBV DNA quantity in peripheral blood at diagnosis | ||||
| Mononuclear cells, log copies/μg DNA, mean | 4.3 ± 0.9 | 4.2 ± 0.9 | 4.5 ± 0.8 | NS |
| Plasma, log copies/mL, mean | 3.3 ± 1.7 | 3.5 ± 1.6 | 3.1 ± 2.0 | NS |
| EBV clonality, monoclonal/oligoclonal/polyclonal | 64/8/4 | 36/4/3 | 28/4/1 | NS |
| TCR rearrangement, any rearrangement/none | 42/48 | 36/20 | 6/28 | < .001 |
| Chromosomal aberration (abnormal/normal cases) | 6/84 | 4/50 | 2/34 | NS |
| Symptoms and signs at diagnosis, n (%) | ||||
| Fever | 98 (91) | 59 (92) | 39 (89) | NS |
| Liver dysfunction | 83 (77) | 49 (77) | 34 (77) | NS |
| Splenomegaly | 64 (59) | 39 (61) | 25 (57) | NS |
| Thrombocytopenia | 47 (44) | 26 (41) | 21 (48) | NS |
| Anemia | 46 (43) | 29 (45) | 17 (39) | NS |
| Lymphadenopathy | 41 (38) | 27 (42) | 14 (32) | NS |
| Hemophagocytic syndrome | 38 (36) | 23 (36) | 15 (34) | NS |
| Hypersensitivity to mosquito bites (HMB) | 32 (30) | 3 (5) | 29 (43) | < .001 |
| Hydroa vacciniforme-like eruption (HV-LE) | 15 (14) | 8 (13) | 7 (16) | NS |
| HMB+HV−LE+ | 5 (5) | 0 (0) | 5 (11) | .001 |
| HMB−HV−LE+ | 10 (9) | 8 (13) | 2 (5) | NS |
| Chemotherapy, n (%) | 70 (65) | 45 (70) | 25 (57) | NS |
| HSCT, n (%) | 59 (55) | 32 (50) | 27 (61) | NS |
| Outcome, n (%) | ||||
| Dead | 47 (44) | 27 (42) | 20 (45) | NS |
| Alive | 61 (57) | 37 (58) | 27 (61) | NS |
| Stable disease | 11 (10) | 8 (13) | 3 (7) | NS |
| Complete remission | 46 (43) | 26 (41) | 20 (20) | NS |
| Partial remission | 4 (4) | 3 (5) | 1 (2) | NS |
| . | Total cells (n = 108) . | T cells (n = 64) . | NK cells (n = 44) . | P* . |
|---|---|---|---|---|
| Sex (male/female) | 50/58 | 27/37 | 23/21 | NS |
| Age at disease onset, y | 12.1 ± 10.6 | 12.7 ± 10.3 | 11.3 ± 11.0 | NS |
| Clinical category at diagnosis, n | ||||
| CAEBV | 80 | 47 | 33 | NS |
| HLH | 15 | 12 | 3 | .066 |
| Severe mosquito bite allergy | 9 | 1 | 8 | .003 |
| Hydroa vacciniforme | 4 | 4 | 0 | NS |
| Past history of infectious mononucleosis, n (%) | 37 (34) | 24 (22) | 13 (12) | NS |
| Primary infection at diagnosis, n (%) | 19 (18) | 16 (15) | 3 (3) | .012 |
| EBV DNA quantity in peripheral blood at diagnosis | ||||
| Mononuclear cells, log copies/μg DNA, mean | 4.3 ± 0.9 | 4.2 ± 0.9 | 4.5 ± 0.8 | NS |
| Plasma, log copies/mL, mean | 3.3 ± 1.7 | 3.5 ± 1.6 | 3.1 ± 2.0 | NS |
| EBV clonality, monoclonal/oligoclonal/polyclonal | 64/8/4 | 36/4/3 | 28/4/1 | NS |
| TCR rearrangement, any rearrangement/none | 42/48 | 36/20 | 6/28 | < .001 |
| Chromosomal aberration (abnormal/normal cases) | 6/84 | 4/50 | 2/34 | NS |
| Symptoms and signs at diagnosis, n (%) | ||||
| Fever | 98 (91) | 59 (92) | 39 (89) | NS |
| Liver dysfunction | 83 (77) | 49 (77) | 34 (77) | NS |
| Splenomegaly | 64 (59) | 39 (61) | 25 (57) | NS |
| Thrombocytopenia | 47 (44) | 26 (41) | 21 (48) | NS |
| Anemia | 46 (43) | 29 (45) | 17 (39) | NS |
| Lymphadenopathy | 41 (38) | 27 (42) | 14 (32) | NS |
| Hemophagocytic syndrome | 38 (36) | 23 (36) | 15 (34) | NS |
| Hypersensitivity to mosquito bites (HMB) | 32 (30) | 3 (5) | 29 (43) | < .001 |
| Hydroa vacciniforme-like eruption (HV-LE) | 15 (14) | 8 (13) | 7 (16) | NS |
| HMB+HV−LE+ | 5 (5) | 0 (0) | 5 (11) | .001 |
| HMB−HV−LE+ | 10 (9) | 8 (13) | 2 (5) | NS |
| Chemotherapy, n (%) | 70 (65) | 45 (70) | 25 (57) | NS |
| HSCT, n (%) | 59 (55) | 32 (50) | 27 (61) | NS |
| Outcome, n (%) | ||||
| Dead | 47 (44) | 27 (42) | 20 (45) | NS |
| Alive | 61 (57) | 37 (58) | 27 (61) | NS |
| Stable disease | 11 (10) | 8 (13) | 3 (7) | NS |
| Complete remission | 46 (43) | 26 (41) | 20 (20) | NS |
| Partial remission | 4 (4) | 3 (5) | 1 (2) | NS |
NS indicates not significant.
P < .10 are shown; P < .05 (shown in bold) are statistically significant.