SF-36 scale scores and adjusted mean differences between the overall CML population and the matched control group
| SF-36 scales . | CML patients, mean (SD) . | Matched control group, mean (SD) . | Mean difference* (95% CI) . | P . |
|---|---|---|---|---|
| Physical health | ||||
| Physical functioning | 76.8 (24.8) | 80.5 (25.4) | −3.9 (−6.7; −1.1) | .006 |
| Role physical | 61.6 (42.2) | 73.0 (40.2) | −11.5 (−16.8; −6.3)† | < .001‡ |
| Bodily pain | 70.4 (26.2) | 70.7 (28.7) | −0.3 (−3.7; 3.2) | .882 |
| General health | 52.7 (22.6) | 61.2 (22.9) | −8.9 (−11.7; −6.0)† | < .001‡ |
| PCS | 46.0 (9.6) | 48.2 (10.3) | −2.4 (−3.6; −1.3)† | < .001§ |
| Mental health | ||||
| Vitality | 56.2 (21.2) | 60.7 (20.8) | −4.6 (−7.4; −1.8) | .001‡ |
| Social functioning | 73.9 (22.7) | 76.7 (24.3) | −2.9 (−6.0; 0.2) | .069 |
| Role emotional | 64.5 (40.7) | 73.9 (38.0) | −9.6 (−14.9; −4.3)† | < .001‡ |
| Mental health | 67.1 (19.8) | 66.3 (21.7) | 0.6 (−2.1; 3.4) | .659 |
| MCS | 49.3 (9.8) | 50.2 (9.7) | −0.9 (−2.3; 0.4) | .166 |
| SF-36 scales . | CML patients, mean (SD) . | Matched control group, mean (SD) . | Mean difference* (95% CI) . | P . |
|---|---|---|---|---|
| Physical health | ||||
| Physical functioning | 76.8 (24.8) | 80.5 (25.4) | −3.9 (−6.7; −1.1) | .006 |
| Role physical | 61.6 (42.2) | 73.0 (40.2) | −11.5 (−16.8; −6.3)† | < .001‡ |
| Bodily pain | 70.4 (26.2) | 70.7 (28.7) | −0.3 (−3.7; 3.2) | .882 |
| General health | 52.7 (22.6) | 61.2 (22.9) | −8.9 (−11.7; −6.0)† | < .001‡ |
| PCS | 46.0 (9.6) | 48.2 (10.3) | −2.4 (−3.6; −1.3)† | < .001§ |
| Mental health | ||||
| Vitality | 56.2 (21.2) | 60.7 (20.8) | −4.6 (−7.4; −1.8) | .001‡ |
| Social functioning | 73.9 (22.7) | 76.7 (24.3) | −2.9 (−6.0; 0.2) | .069 |
| Role emotional | 64.5 (40.7) | 73.9 (38.0) | −9.6 (−14.9; −4.3)† | < .001‡ |
| Mental health | 67.1 (19.8) | 66.3 (21.7) | 0.6 (−2.1; 3.4) | .659 |
| MCS | 49.3 (9.8) | 50.2 (9.7) | −0.9 (−2.3; 0.4) | .166 |
CML indicates chronic myeloid leukemia; PCS, physical component summary; MCS, mental component summary; SD, standard deviation; and CI, confidence interval.
Mean differences adjusted for age, sex, education, geographical area, and marital status.
Exceeds minimally important difference (ie, 8 points for the SF-36 scales and 2 points for the PCS and MCS scores).
Statistically significant after Bonferroni adjustment (adjusted alpha = 0.05/8 = 0.006 25).
Statistically significant (alpha = 0.05).