Reactions to hTERT/survivin vaccinations in patients in arm A (n = 28) at different time points
| . | Before transplantation, n (%) . | Day 14, n (%) . | Day 42, n (%) . | Day 90, n (%) . |
|---|---|---|---|---|
| Temperature ≥ 100°F | 3 (11) | 9 (32)* | 2 (7) | 1 (4) |
| Pain at injection site(≥ grade II) | 9 (32) | 9 (32) | 18 (64) | 17 (61) |
| Loss of appetite (≥ grade II) | 2 (7) | 8 (29) | 6 (21) | 3 (11) |
| Loss of energy (≥ grade II) | 6 (21) | 13 (46) | 12 (43) | 10 (36) |
| Headaches (≥ grade II) | 2 (7) | 2 (7) | 3 (11) | 4 (14) |
| Muscle aches (≥ grade II) | 9 (32) | 8 (29) | 12 (43) | 14 (50) |
| Nausea/vomiting (≥ grade II) | 1 (4) | 10 (36)* | 5 (18) | 1 (4) |
| Redness or induration(≥ 12 mm) | 13 (46) | 10 (36) | 20 (71)* | 17 (61) |
| Redness or induration(≥ 36 mm) | 11 (39) | 7 (25) | 13 (46) | 16 (57) |
| Redness or induration(> 50 mm) | 7 (25) | 2 (7) | 6 (21) | 12 (43)* |
| . | Before transplantation, n (%) . | Day 14, n (%) . | Day 42, n (%) . | Day 90, n (%) . |
|---|---|---|---|---|
| Temperature ≥ 100°F | 3 (11) | 9 (32)* | 2 (7) | 1 (4) |
| Pain at injection site(≥ grade II) | 9 (32) | 9 (32) | 18 (64) | 17 (61) |
| Loss of appetite (≥ grade II) | 2 (7) | 8 (29) | 6 (21) | 3 (11) |
| Loss of energy (≥ grade II) | 6 (21) | 13 (46) | 12 (43) | 10 (36) |
| Headaches (≥ grade II) | 2 (7) | 2 (7) | 3 (11) | 4 (14) |
| Muscle aches (≥ grade II) | 9 (32) | 8 (29) | 12 (43) | 14 (50) |
| Nausea/vomiting (≥ grade II) | 1 (4) | 10 (36)* | 5 (18) | 1 (4) |
| Redness or induration(≥ 12 mm) | 13 (46) | 10 (36) | 20 (71)* | 17 (61) |
| Redness or induration(≥ 36 mm) | 11 (39) | 7 (25) | 13 (46) | 16 (57) |
| Redness or induration(> 50 mm) | 7 (25) | 2 (7) | 6 (21) | 12 (43)* |
Significantly higher than some of the earlier time points (P < .05), except for temperature > 100°F, which was significantly higher than a later time point, and nausea/vomiting, which was significantly higher than a later time point and an earlier time point.