Histopathologic GVHD scores
| Animal . | Treatment regimen . | Lung . | Liver . | Colon . | Total score . | Average total score ± SD . |
|---|---|---|---|---|---|---|
| R.1 | No treatment | 2 | 2.5 | 3 | 7.5 | 7.83 ± 0.58 |
| R.2 | No treatment | 3 | 2.5 | 2 | 7.5 | |
| R.3 | No treatment | 4 | 2.5 | 2 | 8.5 | |
| R.4 | CoBS | 3 | 0.5 | 3 | 6.5 | 3 ± 2.12 |
| R.5 | CoBS | 0 | 0 | 1.5 | 1.5 | |
| R.6 | CoBS | 0 | 0.5 | 1 | 1.5 | |
| R.7 | CoBS | 1 | 1 | 1.5 | 3.5 | |
| R.9 | CoBS | 1 | 0.5 | 0.5 | 2 | |
| R.10 | Autologous transplantation | 0.5 | 0.5 | 0.5 | 1.5 | NA |
| R.11 | No treatment, MHC matched | 3.5 | 3 | 1.5 | 8 | NA |
| R.12 | Irradiation control | 0 | 0 | 0.5 | 0.5 | NA |
| Normal animal, no irradiation | 0 | 0 | 1 | 1 | 1.25 ± 0.35 | |
| Normal animal, no irradiation | 0 | 0 | 1.5 | 1.5 |
| Animal . | Treatment regimen . | Lung . | Liver . | Colon . | Total score . | Average total score ± SD . |
|---|---|---|---|---|---|---|
| R.1 | No treatment | 2 | 2.5 | 3 | 7.5 | 7.83 ± 0.58 |
| R.2 | No treatment | 3 | 2.5 | 2 | 7.5 | |
| R.3 | No treatment | 4 | 2.5 | 2 | 8.5 | |
| R.4 | CoBS | 3 | 0.5 | 3 | 6.5 | 3 ± 2.12 |
| R.5 | CoBS | 0 | 0 | 1.5 | 1.5 | |
| R.6 | CoBS | 0 | 0.5 | 1 | 1.5 | |
| R.7 | CoBS | 1 | 1 | 1.5 | 3.5 | |
| R.9 | CoBS | 1 | 0.5 | 0.5 | 2 | |
| R.10 | Autologous transplantation | 0.5 | 0.5 | 0.5 | 1.5 | NA |
| R.11 | No treatment, MHC matched | 3.5 | 3 | 1.5 | 8 | NA |
| R.12 | Irradiation control | 0 | 0 | 0.5 | 0.5 | NA |
| Normal animal, no irradiation | 0 | 0 | 1 | 1 | 1.25 ± 0.35 | |
| Normal animal, no irradiation | 0 | 0 | 1.5 | 1.5 |
GVHD indicates graft-versus-host disease; CoBS, costimulation blockade and sirolimus; NA, not applicable; and MHC, major histocompatibility complex.