Table 1

Characteristics of the study population, with or without CAD

CharacteristicCAD-free (n = 291)CAD (n = 692)P
Age, y 57.8 ± 12.5 60.9 ± 9.5 < .001* 
Male sex, % 68.6 80.3 < .001† 
Body mass index, kg/m2 25.5 ± 3.5 26.6 ± 3.4 < .001* 
Hypertension, % 36.1 63.5 < .001† 
Smoking, % 43.1 67.9 < .001† 
Diabetes, % 6.9 17.0 < .001† 
Estimated GFR, mL/min‡ 75 ± 20 73 ± 17 .060* 
Lipid-lowering therapies, % 14.4 35.8 < .001† 
Total cholesterol, mM 5.51 ± 1.06 5.75 ± 1.14 .003* 
LDL-cholesterol, mM 3.55 ± 0.92 3.86 ± 0.99 < .001* 
HDL-cholesterol, mM 1.41 ± 0.40 1.21 ± 0.31 < .001* 
Total cholesterol/HDL-cholesterol ratio 4.17 ± 1.29 5.06 ± 1.60 < .001* 
Triglycerides, mM 1.51 ± 0.69 1.97 ± 1.17 < .001* 
hs-CRP, mg/L 1.93 (1.67-2.22) 3.33 (3.04-3.65) < .001* 
FVIII, IU/dL 149 ± 47 172 ± 55 < .001* 
rs688, %    
    CC 37.5 30.1  
    CT 42.3 48.4 .071† 
    TT 20.2 21.5  
    Carrier T (vs CC) 62.5 69.9 .023† 
rs2228671, %§    
    CC 78.0 79.4  
    CT 20.9 19.3 .797† 
    TT 1.1 1.3  
    Carrier T (vs CC) 22.0 20.6 .622† 
rs1122608, %‖    
    GG 47.4 58.5  
    GT 43.2 36.3 .003† 
    TT 9.4 5.2  
    Carrier T (vs GG) 52.6 41.5 .002† 
CharacteristicCAD-free (n = 291)CAD (n = 692)P
Age, y 57.8 ± 12.5 60.9 ± 9.5 < .001* 
Male sex, % 68.6 80.3 < .001† 
Body mass index, kg/m2 25.5 ± 3.5 26.6 ± 3.4 < .001* 
Hypertension, % 36.1 63.5 < .001† 
Smoking, % 43.1 67.9 < .001† 
Diabetes, % 6.9 17.0 < .001† 
Estimated GFR, mL/min‡ 75 ± 20 73 ± 17 .060* 
Lipid-lowering therapies, % 14.4 35.8 < .001† 
Total cholesterol, mM 5.51 ± 1.06 5.75 ± 1.14 .003* 
LDL-cholesterol, mM 3.55 ± 0.92 3.86 ± 0.99 < .001* 
HDL-cholesterol, mM 1.41 ± 0.40 1.21 ± 0.31 < .001* 
Total cholesterol/HDL-cholesterol ratio 4.17 ± 1.29 5.06 ± 1.60 < .001* 
Triglycerides, mM 1.51 ± 0.69 1.97 ± 1.17 < .001* 
hs-CRP, mg/L 1.93 (1.67-2.22) 3.33 (3.04-3.65) < .001* 
FVIII, IU/dL 149 ± 47 172 ± 55 < .001* 
rs688, %    
    CC 37.5 30.1  
    CT 42.3 48.4 .071† 
    TT 20.2 21.5  
    Carrier T (vs CC) 62.5 69.9 .023† 
rs2228671, %§    
    CC 78.0 79.4  
    CT 20.9 19.3 .797† 
    TT 1.1 1.3  
    Carrier T (vs CC) 22.0 20.6 .622† 
rs1122608, %‖    
    GG 47.4 58.5  
    GT 43.2 36.3 .003† 
    TT 9.4 5.2  
    Carrier T (vs GG) 52.6 41.5 .002† 
*

By t test.

†

By χ2 test.

‡

GFR is estimated by the abbreviated Modification of Diet in Renal Disease equation.

§

Data about rs2228671 genotype were available for 958 subjects.

‖

Data about rs1122608 genotype were available for 916 subjects.

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