Characteristics and prognostic scores associated with the JAK2 46/1 haplotype in 199 patients with splanchnic vein thrombosis
| . | rs12343867 genotype (SVT) . | P1* . | P2* . | P3* . | rs12343867 genotype (JAK2V617F-negative SVT) . | P1* . | P2* . | P3* . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC, n = 23 . | CT, n = 83 . | TT, n = 93 . | CC, n = 14 . | CT, n = 55 . | TT, n = 76 . | |||||||
| Age, y | 38.7 (31-61) | 42.9 (31-52) | 46.3 (34-57) | .61 | .74 | .33 | 37.9 (30-60) | 42.8 (31-52) | 46.0 (33-57) | .63 | .76 | .34 |
| Males, % | 10 (43) | 31 (37) | 47 (51) | .21 | .54 | .09 | 10 (71) | 18 (33) | 40 (53) | .01 | .19 | .15 |
| Hemoglobin, mmol/L | 9.5 (8.1-10.5) | 8.2 (7.1-9.1) | 8.3 (6.9-9.5) | < .01 | < .01 | .79 | 9.6 (7.8-10.6) | 7.9 (7.0-8.8) | 8.1 (6.6-9.1) | .02 | < .01 | .38 |
| Hematocrit, % | 47.2 (41-51) | 40.0 (36-44) | 40.2 (34-45) | < .01 | < .01 | .15 | 47.0 (38-51) | 39.5 (36-43) | 38.9 (33-43) | .02 | < .01 | .10 |
| RBC count, ×109/L | 5.6 (4.8-6.3) | 4.6 (4.2-5.3) | 4.6 (3.8-5.2) | < .01 | < .01 | .24 | 5.4 (4.8-5.7) | 4.5 (4.2-5.0) | 4.4 (3.8-5.0) | .04 | .02 | .18 |
| WBC count, ×109/L | 10.5 (7.3-13.7) | 10.1 (7.2-13.3) | 9.3 (6.5-12.5) | .34 | .17 | .20 | 8.0 (7.0-13.2) | 8.8 (6.0-11.5) | 8.6 (6.1-11.4) | .85 | .65 | .59 |
| Platelet count, ×109/L | 357 (217-461) | 235 (155-418) | 231 (138-394) | .17 | .06 | .35 | 242 (167-390) | 188 (141-336) | 220 (124-339) | .76 | .51 | .85 |
| ALT, ULN | 1.3 (1.0-6.7) | 1.2 (0.8-2.7) | 1.0 (0.7-2.4) | .11 | .04 | .11 | 1.1 (0.9-3.6) | 1.0 (0.7-2.1) | 1.0 (0.6-2.3) | .58 | .35 | .49 |
| Serum bilirubin, μmol/L | 28 (15-44) | 20 (12-36) | 24 (13-38) | .32 | .39 | .65 | 22 (14-45) | 17 (13-29) | 22 (13-38) | .59 | .79 | .52 |
| Albumin, g/L | 34 (30-38) | 34 (29-39) | 33 (28-40) | .95 | .88 | .76 | 34 (25-35) | 34 (29-39) | 33 (27-40) | .83 | .76 | .82 |
| Splenomegaly, % | 16 (70) | 38 (46) | 42 (46) | .11 | .045 | .46 | 7 (100) | 20 (36) | 33 (45) | .53 | .71 | .51 |
| . | rs12343867 genotype (SVT) . | P1* . | P2* . | P3* . | rs12343867 genotype (JAK2V617F-negative SVT) . | P1* . | P2* . | P3* . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC, n = 23 . | CT, n = 83 . | TT, n = 93 . | CC, n = 14 . | CT, n = 55 . | TT, n = 76 . | |||||||
| Age, y | 38.7 (31-61) | 42.9 (31-52) | 46.3 (34-57) | .61 | .74 | .33 | 37.9 (30-60) | 42.8 (31-52) | 46.0 (33-57) | .63 | .76 | .34 |
| Males, % | 10 (43) | 31 (37) | 47 (51) | .21 | .54 | .09 | 10 (71) | 18 (33) | 40 (53) | .01 | .19 | .15 |
| Hemoglobin, mmol/L | 9.5 (8.1-10.5) | 8.2 (7.1-9.1) | 8.3 (6.9-9.5) | < .01 | < .01 | .79 | 9.6 (7.8-10.6) | 7.9 (7.0-8.8) | 8.1 (6.6-9.1) | .02 | < .01 | .38 |
| Hematocrit, % | 47.2 (41-51) | 40.0 (36-44) | 40.2 (34-45) | < .01 | < .01 | .15 | 47.0 (38-51) | 39.5 (36-43) | 38.9 (33-43) | .02 | < .01 | .10 |
| RBC count, ×109/L | 5.6 (4.8-6.3) | 4.6 (4.2-5.3) | 4.6 (3.8-5.2) | < .01 | < .01 | .24 | 5.4 (4.8-5.7) | 4.5 (4.2-5.0) | 4.4 (3.8-5.0) | .04 | .02 | .18 |
| WBC count, ×109/L | 10.5 (7.3-13.7) | 10.1 (7.2-13.3) | 9.3 (6.5-12.5) | .34 | .17 | .20 | 8.0 (7.0-13.2) | 8.8 (6.0-11.5) | 8.6 (6.1-11.4) | .85 | .65 | .59 |
| Platelet count, ×109/L | 357 (217-461) | 235 (155-418) | 231 (138-394) | .17 | .06 | .35 | 242 (167-390) | 188 (141-336) | 220 (124-339) | .76 | .51 | .85 |
| ALT, ULN | 1.3 (1.0-6.7) | 1.2 (0.8-2.7) | 1.0 (0.7-2.4) | .11 | .04 | .11 | 1.1 (0.9-3.6) | 1.0 (0.7-2.1) | 1.0 (0.6-2.3) | .58 | .35 | .49 |
| Serum bilirubin, μmol/L | 28 (15-44) | 20 (12-36) | 24 (13-38) | .32 | .39 | .65 | 22 (14-45) | 17 (13-29) | 22 (13-38) | .59 | .79 | .52 |
| Albumin, g/L | 34 (30-38) | 34 (29-39) | 33 (28-40) | .95 | .88 | .76 | 34 (25-35) | 34 (29-39) | 33 (27-40) | .83 | .76 | .82 |
| Splenomegaly, % | 16 (70) | 38 (46) | 42 (46) | .11 | .045 | .46 | 7 (100) | 20 (36) | 33 (45) | .53 | .71 | .51 |
Continuous data are presented as median (IQR range); categorical data as mean (%).
SVT indicates splanchnic vein thrombosis; RBC, red blood cell; WBC, white blood cell; ALT, alanine aminotransferase; and ULN, upper limit of normal value.
P1, P value for genotype comparisons (CC/CT/TT); P2, P value for CC vs TT genotype comparisons; P3, P value for CC/CT vs TT genotype comparisons.