WHO classification of DLBCL2
| Classifications . |
|---|
| DLBCL, not otherwise specified (NOS) |
| Common morphologic variants |
| Centroblastic |
| Immunoblastic |
| Anaplastic |
| Rare morphologic variants |
| Molecular subgroups |
| Germinal center B cell–like (GCB) |
| Activated B cell–like (ABC) |
| Immunohistochemical subgroups |
| CD5-positive DLBCL |
| Germinal center B cell–like (GCB) |
| Nongerminal center B cell–like (non-GCB) |
| Diffuse large B-cell lymphoma subtypes |
| T-cell/histiocyte-rich large B-cell lymphoma |
| Primary DLBCL of the CNS |
| Primary cutaneous DLBCL, leg type |
| EBV-positive DLBCL of the elderly |
| Other lymphomas of large B cells |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| ALK-positive LBCL |
| Plasmablastic lymphoma |
| Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease |
| Primary effusion lymphoma |
| Borderline cases |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma |
| Classifications . |
|---|
| DLBCL, not otherwise specified (NOS) |
| Common morphologic variants |
| Centroblastic |
| Immunoblastic |
| Anaplastic |
| Rare morphologic variants |
| Molecular subgroups |
| Germinal center B cell–like (GCB) |
| Activated B cell–like (ABC) |
| Immunohistochemical subgroups |
| CD5-positive DLBCL |
| Germinal center B cell–like (GCB) |
| Nongerminal center B cell–like (non-GCB) |
| Diffuse large B-cell lymphoma subtypes |
| T-cell/histiocyte-rich large B-cell lymphoma |
| Primary DLBCL of the CNS |
| Primary cutaneous DLBCL, leg type |
| EBV-positive DLBCL of the elderly |
| Other lymphomas of large B cells |
| Primary mediastinal (thymic) large B-cell lymphoma |
| Intravascular large B-cell lymphoma |
| DLBCL associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| ALK-positive LBCL |
| Plasmablastic lymphoma |
| Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease |
| Primary effusion lymphoma |
| Borderline cases |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma |
| B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma |
ALK indicates anaplastic lymphoma receptor tyrosine kinase; and HHV8, human herpesvirus 8.