Combination of IDH1R132mut with other molecular markers in AML with normal karyotype
| Mutation . | cases analyzed . | IDH1 wt . | IDH1 mutated . | Difference compared with respective WT . |
|---|---|---|---|---|
| NPM1wt | 318 | 28 (8.1%) | ||
| NPM1mut | 651 | 268 | 37 (12.1%) | ↑ P = .090 |
| FLT3-wt | 431 | 50 (10.4%) | ||
| FLT3-ITD | 644 | 149 | 14 (8.6%) | n.s. |
| FLT3-TKDwt | 325 | 40 (11.0%) | ||
| FLT3-TKDmut | 390 | 24 | 1 (4.0%) | n.s. |
| NRASwt | 235 | 24 (9.3%) | ||
| NRASmut | 290 | 29 | 2 (6.5%) | n.s. |
| MLLwt | 551 | 55 (9.1%) | ||
| MLL-PTD | 654 | 39 | 9 (18.8%) | ↑ P = .041 |
| CEBPAwt | 406 | 37 (8.4%) | ||
| CEBPAmut | 478 | 35 | 0 (0%) | ↓ P = .097 |
| RUNX1wt | 124 | 13 (9.5%) | ||
| RUNXmut | 192 | 54 | 1 (1.8%) | ↓ P = .072 |
| JAK2V617wt | 198 | 11 (5.3%) | ||
| JAK2V617mut | 228 | 16 | 3 (15.8%) | n.s. |
| Mutation . | cases analyzed . | IDH1 wt . | IDH1 mutated . | Difference compared with respective WT . |
|---|---|---|---|---|
| NPM1wt | 318 | 28 (8.1%) | ||
| NPM1mut | 651 | 268 | 37 (12.1%) | ↑ P = .090 |
| FLT3-wt | 431 | 50 (10.4%) | ||
| FLT3-ITD | 644 | 149 | 14 (8.6%) | n.s. |
| FLT3-TKDwt | 325 | 40 (11.0%) | ||
| FLT3-TKDmut | 390 | 24 | 1 (4.0%) | n.s. |
| NRASwt | 235 | 24 (9.3%) | ||
| NRASmut | 290 | 29 | 2 (6.5%) | n.s. |
| MLLwt | 551 | 55 (9.1%) | ||
| MLL-PTD | 654 | 39 | 9 (18.8%) | ↑ P = .041 |
| CEBPAwt | 406 | 37 (8.4%) | ||
| CEBPAmut | 478 | 35 | 0 (0%) | ↓ P = .097 |
| RUNX1wt | 124 | 13 (9.5%) | ||
| RUNXmut | 192 | 54 | 1 (1.8%) | ↓ P = .072 |
| JAK2V617wt | 198 | 11 (5.3%) | ||
| JAK2V617mut | 228 | 16 | 3 (15.8%) | n.s. |
wt indicates wild-type, n.s., not significant; ↑, elevated; and ↓, decreased.