In vitro spiking experiments (step 1)
| Patient no. . | ETP (nM.min) . | ||||||
|---|---|---|---|---|---|---|---|
| rFVIIa . | APCC . | ||||||
| 0 μg/kg (PRP) . | 90 μg/kg (PRP) . | 200 μg/kg (PRP) . | 270 μg/kg (PRP) . | 0 U/kg (PPP) . | 75 U/kg (PPP) . | 100 U/kg (PPP) . | |
| 1 | 315 | 1067 | 1315 (normalized) | 1365 (normalized) | 289 | 883 | 1012 |
| 2 | 410 | 1650 (normalized) | 2337 | 3004 | 356 | 1378 (normalized) | 2676 |
| 3 | 164 | 805 | 1004 | 1051 | 110 | 1226 (normalized) | 1526 (normalized) |
| 4 | 188 | 283 | 344 | 447 | 197 | 634 | 898 |
| 5 | 196 | 462 | 826 | 844 | 186 | 889 | 930 |
| 6 | 485 | 1530 (normalized) | 1650 (normalized) | 1943 (normalized) | 399 | 1004 | 1054 |
| Patient no. . | ETP (nM.min) . | ||||||
|---|---|---|---|---|---|---|---|
| rFVIIa . | APCC . | ||||||
| 0 μg/kg (PRP) . | 90 μg/kg (PRP) . | 200 μg/kg (PRP) . | 270 μg/kg (PRP) . | 0 U/kg (PPP) . | 75 U/kg (PPP) . | 100 U/kg (PPP) . | |
| 1 | 315 | 1067 | 1315 (normalized) | 1365 (normalized) | 289 | 883 | 1012 |
| 2 | 410 | 1650 (normalized) | 2337 | 3004 | 356 | 1378 (normalized) | 2676 |
| 3 | 164 | 805 | 1004 | 1051 | 110 | 1226 (normalized) | 1526 (normalized) |
| 4 | 188 | 283 | 344 | 447 | 197 | 634 | 898 |
| 5 | 196 | 462 | 826 | 844 | 186 | 889 | 930 |
| 6 | 485 | 1530 (normalized) | 1650 (normalized) | 1943 (normalized) | 399 | 1004 | 1054 |