HRs and 95% CIs for selected arterial and venous thromboses among 5326 MGUS patients versus 20 161 matched controls
| Category . | 1-year follow-up . | 5-year follow-up . | 10-year follow-up . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MGUS . | Controls . | HR* (95% CI) . | MGUS patients . | Controls . | HR* (95% CI) . | MGUS patients . | Controls . | HR* (95% CI) . | |
| Thrombosis by location | |||||||||
| DVT | 51 | 52 | 3.7 (2.5-5.5) | 129 | 228 | 2.8 (2.2-3.5) | 192 | 377 | 2.6 (2.1-3.2) |
| PE | 34 | 36 | 3.6 (2.3-5.8) | 83 | 150 | 2.2 (1.7-2.9) | 125 | 232 | 2.2 (1.7-2.8) |
| Coronary artery disease† | 232 | 490 | 2.0 (1.7-2.4) | 587 | 1683 | 1.5 (1.3-1.7) | 821 | 2455 | 1.5 (1.3-1.6) |
| Cerebrovascular‡ | 109 | 305 | 1.4 (1.0-1.7) | 308 | 1111 | 1.1 (1.0-1.3) | 447 | 1660 | 1.1 (1.0-1.3) |
| Type of thrombosis | |||||||||
| Arterial thrombosis§ | 325 | 763 | 1.7 (1.5-1.9) | 826 | 2572 | 1.3 (1.2-1.4) | 1158 | 3701 | 1.3 (1.3-1.4) |
| Venous thrombosis‖ | 73 | 83 | 3.4 (2.5-4.6) | 183 | 355 | 2.1 (1.7-2.5) | 273 | 569 | 2.1 (1.8-2.4) |
| Any thrombosis (combined) | |||||||||
| All patients | 601 | 829 | 1.9 (1.7-2.1) | 1167 | 2818 | 1.4 (1.3-1.5) | 1545 | 4081 | 1.4 (1.4-1.5) |
| Males | 339 | 528 | 1.9 (1.6-2.2) | 639 | 1646 | 1.4 (1.3-1.5) | 842 | 2317 | 1.4 (1.3-1.5) |
| Females | 262 | 301 | 1.9 (1.6-2.4) | 528 | 1172 | 1.5 (1.3-1.7) | 703 | 1764 | 1.5 (1.4-1.7) |
| Category . | 1-year follow-up . | 5-year follow-up . | 10-year follow-up . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MGUS . | Controls . | HR* (95% CI) . | MGUS patients . | Controls . | HR* (95% CI) . | MGUS patients . | Controls . | HR* (95% CI) . | |
| Thrombosis by location | |||||||||
| DVT | 51 | 52 | 3.7 (2.5-5.5) | 129 | 228 | 2.8 (2.2-3.5) | 192 | 377 | 2.6 (2.1-3.2) |
| PE | 34 | 36 | 3.6 (2.3-5.8) | 83 | 150 | 2.2 (1.7-2.9) | 125 | 232 | 2.2 (1.7-2.8) |
| Coronary artery disease† | 232 | 490 | 2.0 (1.7-2.4) | 587 | 1683 | 1.5 (1.3-1.7) | 821 | 2455 | 1.5 (1.3-1.6) |
| Cerebrovascular‡ | 109 | 305 | 1.4 (1.0-1.7) | 308 | 1111 | 1.1 (1.0-1.3) | 447 | 1660 | 1.1 (1.0-1.3) |
| Type of thrombosis | |||||||||
| Arterial thrombosis§ | 325 | 763 | 1.7 (1.5-1.9) | 826 | 2572 | 1.3 (1.2-1.4) | 1158 | 3701 | 1.3 (1.3-1.4) |
| Venous thrombosis‖ | 73 | 83 | 3.4 (2.5-4.6) | 183 | 355 | 2.1 (1.7-2.5) | 273 | 569 | 2.1 (1.8-2.4) |
| Any thrombosis (combined) | |||||||||
| All patients | 601 | 829 | 1.9 (1.7-2.1) | 1167 | 2818 | 1.4 (1.3-1.5) | 1545 | 4081 | 1.4 (1.4-1.5) |
| Males | 339 | 528 | 1.9 (1.6-2.2) | 639 | 1646 | 1.4 (1.3-1.5) | 842 | 2317 | 1.4 (1.3-1.5) |
| Females | 262 | 301 | 1.9 (1.6-2.4) | 528 | 1172 | 1.5 (1.3-1.7) | 703 | 1764 | 1.5 (1.4-1.7) |
Adjusted for age, sex, and calendar period at diagnosis.
Angina pectoris, unstable angina, and myocardial infarction.
Cerebral infarction, transient ischemic attack, and cerebral hemorrhage.
Angina pectoris, unstable angina, myocardial infarction, transient ischemic attack, and cerebral infarction.
DVT and PE.