Characteristics of patients with MM and MGUS and their matched controls
| Characteristic . | MGUS patients . | MGUS controls . | MM patients . | MM controls . |
|---|---|---|---|---|
| Total, n | 5326 | 20 161 | 18 627 | 70 991 |
| Sex, n (%) | ||||
| Male | 2642 (49.61) | 9990 (49.55) | 10 026 (53.8) | 38 206 (53.8) |
| Female | 2684 (50.39) | 10 171 (50.45) | 8601 (46.2) | 32 785 (46.2) |
| Median age at diagnosis, y (range) | 71 (22-100) | 71 (22-100) | 71 (19-101) | 71 (19-101) |
| Age group, n (%) | ||||
| Less than 40 y | 114 (2.14) | 446 (2.21) | 140 (0.75) | 547 (0.77) |
| 40-49 y | 336 (6.31) | 1310 (6.50) | 723 (3.88) | 2831 (3.99) |
| 50-59 y | 765 (14.36) | 2963 (14.70) | 2318 (12.44) | 9106 (12.83) |
| 60-69 y | 1210 (22.72) | 4684 (23.33) | 4960 (26.63) | 19 307 (27.20) |
| 70-79 y | 1779 (33.40) | 6756 (33.51) | 6795 (36.48) | 25 809 (36.36) |
| 80 y and older | 1122 (21.07) | 4002 (19.85) | 3691 (19.82) | 13 391 (18.86) |
| Year of MGUS/MM diagnosis, n (%) | ||||
| 1958-1975 | 49 (0.92) | 187 (0.93) | 4094 (22.0) | 15 930 (22.4) |
| 1976-1986 | 432 (8.11) | 1633 (8.10) | 5134 (27.6) | 19 602 (27.6) |
| 1987-1996 | 2265 (42.53) | 8575 (42.53) | 4683 (25.1) | 17 620 (24.8) |
| 1997-2006 | 2580 (48.44) | 9766 (48.44) | 4716 (25.3) | 17 839 (25.1) |
| MGUS isotype, n (%) | ||||
| IgG | 2145 (40.3) | — | — | — |
| IgA | 578 (10.9) | — | — | — |
| IgM | 530 (10.0) | — | — | — |
| IgD | 2 (0.04) | — | — | — |
| Missing | 2071 (38.9) | — | — | — |
| M-protein concentration, n (%) | ||||
| Less than 10 g/L | 1732 (32.5) | — | — | — |
| 10 g/L or more | 1108 (20.8) | — | — | — |
| Missing | 2486 (46.7) | — | — | — |
| Characteristic . | MGUS patients . | MGUS controls . | MM patients . | MM controls . |
|---|---|---|---|---|
| Total, n | 5326 | 20 161 | 18 627 | 70 991 |
| Sex, n (%) | ||||
| Male | 2642 (49.61) | 9990 (49.55) | 10 026 (53.8) | 38 206 (53.8) |
| Female | 2684 (50.39) | 10 171 (50.45) | 8601 (46.2) | 32 785 (46.2) |
| Median age at diagnosis, y (range) | 71 (22-100) | 71 (22-100) | 71 (19-101) | 71 (19-101) |
| Age group, n (%) | ||||
| Less than 40 y | 114 (2.14) | 446 (2.21) | 140 (0.75) | 547 (0.77) |
| 40-49 y | 336 (6.31) | 1310 (6.50) | 723 (3.88) | 2831 (3.99) |
| 50-59 y | 765 (14.36) | 2963 (14.70) | 2318 (12.44) | 9106 (12.83) |
| 60-69 y | 1210 (22.72) | 4684 (23.33) | 4960 (26.63) | 19 307 (27.20) |
| 70-79 y | 1779 (33.40) | 6756 (33.51) | 6795 (36.48) | 25 809 (36.36) |
| 80 y and older | 1122 (21.07) | 4002 (19.85) | 3691 (19.82) | 13 391 (18.86) |
| Year of MGUS/MM diagnosis, n (%) | ||||
| 1958-1975 | 49 (0.92) | 187 (0.93) | 4094 (22.0) | 15 930 (22.4) |
| 1976-1986 | 432 (8.11) | 1633 (8.10) | 5134 (27.6) | 19 602 (27.6) |
| 1987-1996 | 2265 (42.53) | 8575 (42.53) | 4683 (25.1) | 17 620 (24.8) |
| 1997-2006 | 2580 (48.44) | 9766 (48.44) | 4716 (25.3) | 17 839 (25.1) |
| MGUS isotype, n (%) | ||||
| IgG | 2145 (40.3) | — | — | — |
| IgA | 578 (10.9) | — | — | — |
| IgM | 530 (10.0) | — | — | — |
| IgD | 2 (0.04) | — | — | — |
| Missing | 2071 (38.9) | — | — | — |
| M-protein concentration, n (%) | ||||
| Less than 10 g/L | 1732 (32.5) | — | — | — |
| 10 g/L or more | 1108 (20.8) | — | — | — |
| Missing | 2486 (46.7) | — | — | — |
— indicates not applicable.