Demographic and baseline characteristics of the study population according to PETHEMA/HOVON trial
| Characteristic . | LPA99 . | LPA2005 . | P . | ||
|---|---|---|---|---|---|
| Median (range) . | N (%) . | Median (range) . | N (%) . | ||
| Overall | 561 (100) | 402 (100) | |||
| Age, y | 40 (2-83) | 42 (3-83) | |||
| Younger than 18 | 65 (12) | 26 (6) | .01* | ||
| 18-40 | 223 (40) | 168 (42) | |||
| 41-60 | 171 (30) | 150 (37) | |||
| 61-70 | 68 (12) | 36 (9) | |||
| Older than 70 | 34 (6) | 22 (6) | |||
| Sex | |||||
| Male | 270 (48) | 209 (52) | .22 | ||
| Female | 291 (52) | 193 (48) | |||
| ECOG | 1 (0-3) | 1 (0-3) | |||
| 0-1 | 378 (73) | 267 (80) | .02 | ||
| 2 | 102 (20) | 41 (12) | |||
| 3 | 36 (7) | 26 (8) | |||
| Fever | |||||
| No | 334 (60) | 238 (63) | .33 | ||
| Yes | 220 (40) | 137 (37) | |||
| WBC count, ×109/L | 2.2 (0.2-460) | 3.0 (0.3-126) | |||
| 5 or less | 373 (67) | 248 (62) | .13† | ||
| 5-10 | 47 (8) | 36 (9) | |||
| 10-50 | 100 (18) | 96 (24) | |||
| More than 50 | 40 (7) | 22 (5) | |||
| Platelet count, ×109/L | 22 (1-207) | 23 (1-235) | |||
| 40 or less | 432 (77) | 298 (74) | .24 | ||
| More than 40 | 128 (23) | 104 (26) | |||
| Relapse-risk group | |||||
| Low | 107 (19) | 84 (21) | .14 | ||
| Intermediate | 313 (56) | 200 (50) | |||
| High | 140 (25) | 118 (29) | |||
| Hemoglobin, g/dL | 9.2 (3-16.9) | 9.3 (2.4-14.5) | |||
| 10 or less | 361 (65) | 255 (63) | .74 | ||
| More than 10 | 199 (35) | 147 (37) | |||
| Creatinine, mg/dL | 0.9 (0.2-2.4) | 0.8 (0.3-3.1) | |||
| 1.4 or less | 526 (98) | 365 (97) | .48 | ||
| More than 1.4 | 13 (2) | 12 (3) | |||
| Uric acid, mg/dL | 3.9 (0.29-12.7) | 4.1 (1.0-10.5) | |||
| 7 or less | 445 (95) | 327 (96) | .63 | ||
| More than 7 | 24 (5) | 15 (4) | |||
| Fibrinogen, mg/dL | 158 (0-862) | 179 (37-777) | |||
| 170 or less | 280 (54) | 176 (48) | .07 | ||
| More than 170 | 240 (46) | 193 (52) | |||
| Albumin, g/dL | 4.0 (1.7-6.7) | 4.1 (2.0-6.0) | |||
| 3.5 or less | 107 (24) | 66 (20) | .15 | ||
| More than 3.5 | 335 (76) | 267 (80) | |||
| Morphologic subtype | |||||
| Hypergranular | 452 (82) | 296 (80) | .44 | ||
| Microgranular | 99 (18) | 74 (20) | |||
| PML/RARα isoform | |||||
| BCR1/BCR2 | 300 (60) | 146 (55) | .29 | ||
| BCR3 | 204 (40) | 117 (45) | |||
| Characteristic . | LPA99 . | LPA2005 . | P . | ||
|---|---|---|---|---|---|
| Median (range) . | N (%) . | Median (range) . | N (%) . | ||
| Overall | 561 (100) | 402 (100) | |||
| Age, y | 40 (2-83) | 42 (3-83) | |||
| Younger than 18 | 65 (12) | 26 (6) | .01* | ||
| 18-40 | 223 (40) | 168 (42) | |||
| 41-60 | 171 (30) | 150 (37) | |||
| 61-70 | 68 (12) | 36 (9) | |||
| Older than 70 | 34 (6) | 22 (6) | |||
| Sex | |||||
| Male | 270 (48) | 209 (52) | .22 | ||
| Female | 291 (52) | 193 (48) | |||
| ECOG | 1 (0-3) | 1 (0-3) | |||
| 0-1 | 378 (73) | 267 (80) | .02 | ||
| 2 | 102 (20) | 41 (12) | |||
| 3 | 36 (7) | 26 (8) | |||
| Fever | |||||
| No | 334 (60) | 238 (63) | .33 | ||
| Yes | 220 (40) | 137 (37) | |||
| WBC count, ×109/L | 2.2 (0.2-460) | 3.0 (0.3-126) | |||
| 5 or less | 373 (67) | 248 (62) | .13† | ||
| 5-10 | 47 (8) | 36 (9) | |||
| 10-50 | 100 (18) | 96 (24) | |||
| More than 50 | 40 (7) | 22 (5) | |||
| Platelet count, ×109/L | 22 (1-207) | 23 (1-235) | |||
| 40 or less | 432 (77) | 298 (74) | .24 | ||
| More than 40 | 128 (23) | 104 (26) | |||
| Relapse-risk group | |||||
| Low | 107 (19) | 84 (21) | .14 | ||
| Intermediate | 313 (56) | 200 (50) | |||
| High | 140 (25) | 118 (29) | |||
| Hemoglobin, g/dL | 9.2 (3-16.9) | 9.3 (2.4-14.5) | |||
| 10 or less | 361 (65) | 255 (63) | .74 | ||
| More than 10 | 199 (35) | 147 (37) | |||
| Creatinine, mg/dL | 0.9 (0.2-2.4) | 0.8 (0.3-3.1) | |||
| 1.4 or less | 526 (98) | 365 (97) | .48 | ||
| More than 1.4 | 13 (2) | 12 (3) | |||
| Uric acid, mg/dL | 3.9 (0.29-12.7) | 4.1 (1.0-10.5) | |||
| 7 or less | 445 (95) | 327 (96) | .63 | ||
| More than 7 | 24 (5) | 15 (4) | |||
| Fibrinogen, mg/dL | 158 (0-862) | 179 (37-777) | |||
| 170 or less | 280 (54) | 176 (48) | .07 | ||
| More than 170 | 240 (46) | 193 (52) | |||
| Albumin, g/dL | 4.0 (1.7-6.7) | 4.1 (2.0-6.0) | |||
| 3.5 or less | 107 (24) | 66 (20) | .15 | ||
| More than 3.5 | 335 (76) | 267 (80) | |||
| Morphologic subtype | |||||
| Hypergranular | 452 (82) | 296 (80) | .44 | ||
| Microgranular | 99 (18) | 74 (20) | |||
| PML/RARα isoform | |||||
| BCR1/BCR2 | 300 (60) | 146 (55) | .29 | ||
| BCR3 | 204 (40) | 117 (45) | |||