Scoring system for children with ALL according to different treatment protocols
| . | BFM . | COALL . | FRALLE . |
|---|---|---|---|
| Scoring system A | |||
| Induction starting day 8 | |||
| DEXA or PDN 40 mg/m2 | + (0.5 points) | — | + (0.5 points) |
| PDN 60 mg/m2 and ASP 5000-6000 IU/m2 | ++ (1 point) | ||
| Maximum score | 1.0 | 0 | 0.5 |
| Scoring system B | |||
| CVL, Broviac/Port | + (1 point) | + (1 point) | + (1 point) |
| Genetics | |||
| Thrombophilia (n = 1) | + (1 point) | + (1 point) | + (1 point) |
| Thrombophilia (> 1) | + (2 points) | + (2 points) | + (2 points) |
| Maximum score | 3 | 3 | 3 |
| Total score, minimum | 0.5 | 0 | 0.5 |
| Scoring systems A and B, maximum score | 4.0 | 3.0 | 3.5 |
| . | BFM . | COALL . | FRALLE . |
|---|---|---|---|
| Scoring system A | |||
| Induction starting day 8 | |||
| DEXA or PDN 40 mg/m2 | + (0.5 points) | — | + (0.5 points) |
| PDN 60 mg/m2 and ASP 5000-6000 IU/m2 | ++ (1 point) | ||
| Maximum score | 1.0 | 0 | 0.5 |
| Scoring system B | |||
| CVL, Broviac/Port | + (1 point) | + (1 point) | + (1 point) |
| Genetics | |||
| Thrombophilia (n = 1) | + (1 point) | + (1 point) | + (1 point) |
| Thrombophilia (> 1) | + (2 points) | + (2 points) | + (2 points) |
| Maximum score | 3 | 3 | 3 |
| Total score, minimum | 0.5 | 0 | 0.5 |
| Scoring systems A and B, maximum score | 4.0 | 3.0 | 3.5 |
ALL indicates acute lymphoblastic leukemia; BFM, Berlin-Frankfurt-Münster; COALL, Cooperative Acute Lymphoblastic Leukemia; FRALLE, French Acute Lymphoblastic Leukemia; ASP, Escherichia coli asparaginase; CVL, central venous line; DEXA, dexamethasone; and PDN, prednisone.