Association of kinase gene expression signatures, JAK mutations, and IKAROS/IKZF1 deletions with the low- versus high-risk groups defined by the gene expression classifier for RFS
| Genetic feature . | Risk group determined by gene expression classifier for RFS . | Total . | P (Fisher exact) . | |
|---|---|---|---|---|
| Low risk . | High risk . | |||
| Kinase signature | ||||
| Yes | 0 | 38 (39%) | 38 (18%) | < .001 |
| No | 109 | 60 (61%) | 169 (82%) | |
| Total | 109 | 98 (100%) | 207 (100%) | |
| JAK1/JAK2 mutation | ||||
| Yes | 0 | 19 (20%) | 19 (10%) | < .001 |
| No | 105 | 74 (100%) | 179 (90%) | |
| Total | 105 | 93 (100%) | 198 (100%) | |
| IKAROS/IKZF1 deletion | ||||
| Yes | 14 (13%) | 41 (44%) | 55 (28%) | < .001 |
| No | 91 (87%) | 52 (56%) | 143 (72%) | |
| Total | 105 (100%) | 93 (100%) | 198 (100%) | |
| Genetic feature . | Risk group determined by gene expression classifier for RFS . | Total . | P (Fisher exact) . | |
|---|---|---|---|---|
| Low risk . | High risk . | |||
| Kinase signature | ||||
| Yes | 0 | 38 (39%) | 38 (18%) | < .001 |
| No | 109 | 60 (61%) | 169 (82%) | |
| Total | 109 | 98 (100%) | 207 (100%) | |
| JAK1/JAK2 mutation | ||||
| Yes | 0 | 19 (20%) | 19 (10%) | < .001 |
| No | 105 | 74 (100%) | 179 (90%) | |
| Total | 105 | 93 (100%) | 198 (100%) | |
| IKAROS/IKZF1 deletion | ||||
| Yes | 14 (13%) | 41 (44%) | 55 (28%) | < .001 |
| No | 91 (87%) | 52 (56%) | 143 (72%) | |
| Total | 105 (100%) | 93 (100%) | 198 (100%) | |
The gene expression classifier for RFS used in this analysis is the initial classifier developed with 42 probe sets (38 unique genes) provided in supplemental Table 4.