Table 1 Association of RFS with clinical... | American Society of Hematology

Table 1

Association of RFS with clinical and genetic features in the high-risk ALL cohort

Characteristic	Value	Association with RFS*
Characteristic	Value	Hazard ratio	P
Age, y
10 or older	132	1
Younger than 10	75	1.152	.561
Median	13
Range	1-20	.995	.817
Sex
Male	137	1
Female	70	0.769	.320
WBC, K/μL
Median	62.3
Range	1-959	1.003	< .001
MRD at day 29†
Negative	124	1
Positive	67	2.805	< .001
Race
Hispanic or Latino	51	1.644	.049
Other	156	1
MLL
Positive	21	1.061	.881
Negative	186	1
E2A/PBX1
Positive	23	.704	.409
Negative	184	1
CNS
No blasts	160	1
Fewer than 5 blasts	26	1.078	.826
At least 5 blasts	21	0.670	.392

Characteristic	Value	Association with RFS*
Characteristic	Value	Hazard ratio	P
Age, y
10 or older	132	1
Younger than 10	75	1.152	.561
Median	13
Range	1-20	.995	.817
Sex
Male	137	1
Female	70	0.769	.320
WBC, K/μL
Median	62.3
Range	1-959	1.003	< .001
MRD at day 29†
Negative	124	1
Positive	67	2.805	< .001
Race
Hispanic or Latino	51	1.644	.049
Other	156	1
MLL
Positive	21	1.061	.881
Negative	186	1
E2A/PBX1
Positive	23	.704	.409
Negative	184	1
CNS
No blasts	160	1
Fewer than 5 blasts	26	1.078	.826
At least 5 blasts	21	0.670	.392

CNS indicates central nervous system.

Hazard ratio and corresponding P value are based on Cox regression.

Only 191 of 207 patients in the high-risk ALL cohort had flow MRD results at end induction.