Table 4 Cooperative gene mutations in... | American Society of Hematology

Table 4

Cooperative gene mutations in the 32 AML patients with WT1 mutations*

UPNs	Class 1 mutations				Class 2 mutations			NPM1 mutation
UPNs	FLT3/ITD	FLT3/TKD	NRAS	KRAS	RUNX1	CEBPA	MLL/PTD	NPM1 mutation
1, 9, 19, 24	+	—	—	—	—	—	—	—
16, 28	+	—	—	—	—	—	—	+
21	+	—	+	—	—	—	—	+
26	+	—	+	—	—	—	—	—
31	+	—	—	—	—	—	+	—
25	—	+	—	—	+	—	—	—
23	—	+	—	—	—	—	—	+
18	—	—	—	+	—	—	—	—
3	—	—	—	+	—	—	—	—
2, 5, 11, 15, 22, 30, 32	—	—	—	—	—	+	—	—
17	—	—	—	—	+	—	—	—
29	—	—	—	—	—	—	+	—
4	—	—	—	—	—	—	—	+

UPNs	Class 1 mutations				Class 2 mutations			NPM1 mutation
UPNs	FLT3/ITD	FLT3/TKD	NRAS	KRAS	RUNX1	CEBPA	MLL/PTD	NPM1 mutation
1, 9, 19, 24	+	—	—	—	—	—	—	—
16, 28	+	—	—	—	—	—	—	+
21	+	—	+	—	—	—	—	+
26	+	—	+	—	—	—	—	—
31	+	—	—	—	—	—	+	—
25	—	+	—	—	+	—	—	—
23	—	+	—	—	—	—	—	+
18	—	—	—	+	—	—	—	—
3	—	—	—	+	—	—	—	—
2, 5, 11, 15, 22, 30, 32	—	—	—	—	—	+	—	—
17	—	—	—	—	+	—	—	—
29	—	—	—	—	—	—	+	—
4	—	—	—	—	—	—	—	+

A total of 23 of the 32 WT1-mutated patients concurrently had other gene mutations, including 13 (56.5%) with class 1 mutations and 16 (69.6%) with class 2 mutations or NPM1 mutations. None of these patients had KIT, PTPN11, or JAK2 mutation.

UPN indicates unique patient number; and —, negative (not mutated).

View Large

This Feature Is Available To Subscribers Only